Papers/PMID:33870711
Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study.
Journal of the American Heart Association2021The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
K(+) — increases serum potassium concentration
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Findingreplicated ×2“In summary, potassium supplementation significantly increased plasma potassium (mean±SD, 4.3±0.2 mmol/L versus 4.0±0.2 mmol/L; P=0.0002), while there were no differences in plasma creatinine and sodium between the 2 treatments.”
Quoted verbatim from Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study.. - Study
- crossover
- Duration
- 4 weeks
- Dose
- 90 mmol potassium per day as potassium chloride tablets (Kaleorid 750 mg, 3 tablets 3 times daily)
- Population
- 25 healthy normotensive men completing both treatment periods of a placebo-controlled double-blind crossover; fasting sample at end of each 4-week period
Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study.2021PMID:33870711Permalink
K(+) — increases plasma aldosterone concentration
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Findingreplicated ×2“With respect to plasma vasoactive hormones, potassium supplementation significantly increased plasma aldosterone (median [IQR], 440 [336–521] versus 237 [173–386] pmol/L; P<0.0001) corresponding to an estimated difference in median aldosterone of 85% (95% CI, 55–120) between potassium supplementation and placebo.”
Quoted verbatim from Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study.. - Study
- crossover
- Duration
- 4 weeks
- Dose
- 90 mmol potassium per day as potassium chloride tablets (Kaleorid 750 mg, 3 tablets 3 times daily)
- Population
- 25 healthy normotensive men completing both treatment periods of a placebo-controlled double-blind crossover; fasting supine venous sample at end of each 4-week period
Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study.2021PMID:33870711Permalink