Papers/PMID:33597269
Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation.
The Journal of neuroscience : the official journal of the Society for Neuroscience2021The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
Zn(2+) — inhibits NLRP3
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Conversely, zinc supplementation (with ZnCl2) in LPS-primed BMDMs blocked established NLRP3 activators, including silica, by inhibiting IL-1β release (F(5,12) = 122.0, p < 0.001), ASC oligomerization, caspase-1 and gasdermin D cleavage (Bii, C).”
Quoted verbatim from Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation.. - Study
- in vitro · not in humans
- Population
- LPS-primed mouse bone-marrow-derived macrophages stimulated with silica
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