Zn(2+)/Finding
One finding, on its own
A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Inhibits NLRP3
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Conversely, zinc supplementation (with ZnCl2) in LPS-primed BMDMs blocked established NLRP3 activators, including silica, by inhibiting IL-1β release (F(5,12) = 122.0, p < 0.001), ASC oligomerization, caspase-1 and gasdermin D cleavage (Bii, C).”
Quoted verbatim from Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation.. - Study
- in vitro · not in humans
- Population
- LPS-primed mouse bone-marrow-derived macrophages stimulated with silica
Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation.2021PMID:33597269Permalink
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- Everything the graph holds on Zn(2+)
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To cite this finding: https://catalystproject.ai/e/01M5RSP2JJNXKQK2HW269ZWV6A