Papers/PMID:33502533
Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.
Pain medicine (Malden, Mass.)2021The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
meloxicam — increases time to first postoperative analgesic request
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Time from EOS to first use of opioid rescue medication (via IV or oral administration) was significantly longer with meloxicam IV versus placebo (P =.0003) (Table 4).”
Quoted verbatim from Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.. - Study
- RCT
- Dose
- 30 mg IV bolus before incision, then every 24 hours
- Population
- Adults undergoing elective primary total knee arthroplasty; both arms received multimodal analgesia (oral acetaminophen, gabapentin, tranexamic acid, bupivacaine infiltration)
Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.2021PMID:33502533Industry fundedPermalink
What did not
1 finding
meloxicam — no detected effect on hospital length of stay
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The duration of hospital stay was numerically shorter for subjects who received meloxicam IV versus placebo, but the difference was not statistically significant (P =.4935) (Supplemental Digital Content 3, Table S2).”
Quoted verbatim from Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.. - Study
- RCT
- Dose
- 30 mg IV bolus before incision, then every 24 hours
- Population
- Adults undergoing elective primary total knee arthroplasty; hospital stay after surgery
Safety and Efficacy of Perioperative Intravenous Meloxicam for Moderate-to-Severe Pain Management in Total Knee Arthroplasty: A Randomized Clinical Trial.2021PMID:33502533Industry fundedPermalink