Papers/PMID:33468279
Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials.
The British journal of nutrition2021The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
Zn(2+) — decreases interleukin-6 concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Zn could decrease IL-6 levels (standardised mean difference (SMD) = -0·76 pg/ml; 95 % CI -1·28, -0·24; P = 0·004).”
Quoted verbatim from Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials.. - Study
- meta-analysis
- Population
- Subjects aged over 15 years in controlled trials of zinc supplementation
Effect -0.76 standardised mean difference, 95% CI -1.28 to -0.24
Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials.2021PMID:33468279Permalink
What did not
1 finding
Zn(2+) — no detected effect on tumour necrosis factor alpha concentration
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“There was no significant change in TNF-α (SMD = 0·42 pg/ml; 95 % CI -0·31, 1·16; P = 0·257) and IL-2 levels (SMD = 1·64 pg/ml; 95 % CI -1·31, 4·59; P = 0·277) following Zn supplementation.”
Quoted verbatim from Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials.. - Study
- meta-analysis
- Population
- Subjects aged over 15 years in controlled trials of zinc supplementation
Effect 0.42 standardised mean difference, 95% CI -0.31 to 1.16
Profiling inflammatory cytokines following zinc supplementation: a systematic review and meta-analysis of controlled trials.2021PMID:33468279Permalink