Skip to content
Catalyst

PapersPMID:32991046

Differential effects of L- and D-phenylalanine on pancreatic and gastrointestinal hormone release in humans: A randomized crossover study.

Diabetes, obesity & metabolism2021The record ↗

  1. Finding, very limited evidenceno difference foundAd libitum test-meal energy intake

No finding here moved its endpoint.

What did not

1 findingHow to read these marks →
  • No detected effect on ad libitum test-meal energy intake

    very limited

    “L-phenylalanine reduced postprandial glucose area under the curve (AUC)70-150mins relative to placebo (P = .0317) but did not affect subjective appetite or energy intake (P > .05).”
    Study
    crossover
    Duration
    1 day
    Dose studied
    10 g L-phenylalanine, oral, single dose, ad libitum meal 70 minutes after ingestion
    Population
    Eleven participants in an acute randomised double-blind placebo-controlled crossover study; energy intake at an ad libitum meal served 70 minutes after ingestion; L-phenylalanine arm against placebo (a D-phenylalanine arm is not part of this claim)

Study record

Design
crossover trial
Species
human
Population
humans: five participants in a non-randomized dose-finding study and 11 participants in a randomized, double-blind, placebo-controlled crossover study (abstract only)
Participants
11
Comparator
placebo
Duration
not reported
Endpoints measured
8