Papers/PMID:32770661
Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma.
Physiological reports2020The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
sodium chloride — increases plasma glucagon-like peptide-1 (GLP-1)
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“Arterial plasma concentrations of total GLP‐1 increased during glucose + NaCl and glucose alone, however, an apparent plateau (incremental AUC, lasting from 40–80 min) was significantly higher during glucose + NaCl compared with glucose alone.”
Quoted verbatim from Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma.. - Study
- crossover
- Dose
- 6 g (103 mmol) NaCl single oral dose dissolved with 75 g glucose in 500 mL tap water
- Population
- Healthy young men; 6 g oral NaCl added to a 75 g oral glucose load versus the glucose load alone, after a standardised 4-day sodium intake; arterial blood sampling
Increased oral sodium chloride intake in humans amplifies selectively postprandial GLP-1 but not GIP, CCK, and gastrin in plasma.2020PMID:32770661Permalink