PapersPMID:32702899

Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials.

PMID:32702899

Study, every finding: meta-analysis
Population, every finding: Adults with type 2 diabetes in eight randomised trials (2110 patients in the review), pooled across niacin doses and formulations; three trials added niacin to a statin given in both arms; control was placebo or no treatment with the same background therapy

What moved

Decreases triglycerides
moderate
“We noted that niacin supplementation was associated with lower TG level (WMD, –0.37; 95% CI, −0.52 to −0.21; P <.001), and that significant heterogeneity was shown among the included trials (I 2 = 67.8%; P =.005).”
Effect
−0.37 mean difference, 95% CI −0.52 to −0.21
Decreases LDL cholesterol
moderate
“The pooled WMD suggested that niacin supplementation significantly reduced the level of LDL (WMD, −0.42; 95% CI, −0.50 to −0.34; P <.001), and that there was no evidence of heterogeneity (I 2 = 0.0%; P =.590).”
Effect
−0.42 mean difference, 95% CI −0.5 to −0.34
Decreases total cholesterol (TC)
moderate
“The pooled results suggested that niacin supplementation significantly reduced the level of TC (WMD, −0.28; 95% CI, −0.44 to −0.12; P =.001), and that significant heterogeneity was detected across the included trials (I 2 = 74.0%; P =.002).”
Effect
−0.28 mean difference, 95% CI −0.44 to −0.12