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PapersPMID:32665012

The effects of green coffee extract supplementation on glycemic indices and lipid profile in adults: a systematic review and dose-response meta-analysis of clinical trials.

Nutrition journal2020The record ↗

findings
5
compound
1
endpoints
5
no difference found
3
PMID:32665012
  1. Finding, moderate evidencelowersFasting blood glucose
  2. Finding, moderate evidencelowersTotal cholesterol (TC)
  3. Finding, moderate evidenceno difference foundLDL cholesterol
  4. Finding, moderate evidenceno difference foundTriglycerides
  5. Finding, moderate evidenceno difference foundHDL cholesterol
Study, every finding
meta-analysis
Dose studied, every finding
GCE 90 to 6000 mg/day, CGA 13.5 to 1200 mg/day
Population, every finding
Adults (18 years and over) in placebo-controlled trials of green coffee extract lasting at least 2 weeks; participants healthy or overweight, obese, dyslipidaemic, hypertensive, with metabolic syndrome, fatty liver, impaired glucose tolerance or xerotic skin

What moved

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  • Decreases fasting blood glucose

    moderate

    “After combining effect sizes, we found a significant reducing effect of GCE supplementation on FBG levels (WMD: -2.35, 95% CI: − 3.78, − 0.92 mg/dL, P = 0.001).”
    Effect
    −2.35 mean difference, 95% CI −3.78 to −0.92
  • Decreases total cholesterol (TC)

    moderate

    “Combining these effect sizes, a significant reduction was seen in serum concentrations of TC following GCE supplementation (WMD: -4.51, 95% CI: − 8.39, − 0.64 mg/dL, P = 0.02).”
    Effect
    −4.51 mean difference, 95% CI −8.39 to −0.64

What did not

  • No detected effect on LDL cholesterol

    moderate

    “Considering 15 effect sizes from 12 studies which included 642 participants, no significant effect of GCE supplementation on serum concentrations of LDL was found (WMD: -2.02, 95% CI: − 5.58, 1.54 mg/dL, P = 0.26, I 2: 47.6, P = 0.02).”
    Participants
    642
    Effect
    −2.02 mean difference, 95% CI −5.58 to 1.54
  • No detected effect on triglycerides

    moderate

    “Combining 15 effect sizes from these studies revealed no significant effect of GCE supplementation on serum TG concentrations (WMD: -3.17, 95% CI: − 11.82, 5.49 mg/dL, P = 0.47).”
    Effect
    −3.17 mean difference, 95% CI −11.82 to 5.49
  • No detected effect on HDL cholesterol

    moderate

    “Combining 15 effect sizes from these studies revealed no significant effect of GCE supplementation on HDL levels (WMD: 1.08, 95% CI: − 0.22, 2.38 mg/dL, P = 0.10).”
    Effect
    1.08 mean difference, 95% CI −0.22 to 2.38

Study record

Design
meta-analysis
Species
human
Population
Adults (18 years and over) in placebo-controlled trials of green coffee extract supplementation, healthy or with overweight, obesity, dyslipidemia, hypertension, metabolic syndrome, NAFLD, impaired glucose tolerance or xerotic skin
Participants
766
Comparator
placebo
Duration
not reported
Endpoints measured
23