Papers/PMID:32621874
Efficacy of vitamin D3 supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial.
The lancet. HIV2020The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
calciol — increases serum 25-hydroxyvitamin D concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×13“Vitamin D3 supplementation increased post-randomization serum 25(OH)D concentrations as compared to the placebo (P-value for difference in trajectory: <0·0001).”
Quoted verbatim from Efficacy of vitamin D3 supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 12 months
- Dose
- 50,000 IU vitamin D3 weekly for four weeks, then 2000 IU daily to one year, versus matching placebo
- Population
- Adults living with HIV initiating antiretroviral therapy in Dar es Salaam, Tanzania, with baseline serum 25(OH)D below 30 ng/mL; random sample of 400 participants with serial 25(OH)D measures
Efficacy of vitamin D3 supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial.2020PMID:32621874Permalink