PapersPMID:32433978
Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function.
creatineWhat moved
1 findingHow to read these marks →- Is transported by SLC6A8
very limited
“The addition of extracellular creatine (1mM and 10mM) significantly increased intracellular creatine in control cells but not in CRT KD cells.”
- Study
- in vitro · not in humans
- Duration
- 4 days
- Dose studied
- extracellular creatine 1 mM and 10 mM in culture media
- Population
- T84 human intestinal epithelial cells, control versus lentiviral CRT (SLC6A8) knockdown
Study record
- Design
- in vitro / mechanistic study
- Species
- cells / mixed
- Population
- T84 human intestinal epithelial cells with CRT knockdown or overexpression, CRT knockout mouse colonoids, and colon biopsies from patients with IBD and controls; creatine itself added only as extracellular creatine in culture
- Participants
- not reported
- Comparator
- no treatment / observational
- Duration
- not reported
- Endpoints measured
- 37