Papers/PMID:32357187
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.
PloS one2020The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
berberine — inhibits EPHB2
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“The Western blot results further indicated that BBR not only inhibited PA/LPS-induced CHOP and ATF-4 activation but also significantly suppressed PA/LPS-induced ERK activation in primary mouse hepatocytes.”
Quoted verbatim from Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.. - Study
- in vitro · not in humans
- Dose
- 5 uM for 1 h pretreatment
- Population
- Primary mouse hepatocytes from C57BL/6 mice pretreated with berberine 5 uM for 1 h, then palmitic acid and LPS for 6 h
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.2020PMID:32357187Permalink