berberine/Finding
One finding, on its own
A single claim from the graph, with the evidence strength computed from its study, the sentence it was drawn from, and the paper. This address does not change.
Inhibits EPHB2
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“The Western blot results further indicated that BBR not only inhibited PA/LPS-induced CHOP and ATF-4 activation but also significantly suppressed PA/LPS-induced ERK activation in primary mouse hepatocytes.”
Quoted verbatim from Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.. - Study
- in vitro · not in humans
- Dose
- 5 uM for 1 h pretreatment
- Population
- Primary mouse hepatocytes from C57BL/6 mice pretreated with berberine 5 uM for 1 h, then palmitic acid and LPS for 6 h
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.2020PMID:32357187Permalink
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- Everything the graph holds on berberine
- Every compound studied against EPHB2
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To cite this finding: https://catalystproject.ai/e/01M45T4PK8JFXARS4JGAMQ4F68