Papers/PMID:32092951
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.
International journal of molecular sciences2020The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
(-)-epigallocatechin 3-gallate — inhibits DYRK1A
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“As expected, the DYRK1A-ΔC and DYRK1A activities decreased with increasing concentrations of EGCG (Table 1 and Table 2).”
Quoted verbatim from Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.. - Study
- in vitro · not in humans
- Dose
- concentrations up to 100 uM
- Population
- Purified recombinant DYRK1A catalytic domain and native human DYRK1A, in vitro kinase assay with fluorescent peptide substrate and 1 mM ATP
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.2020PMID:32092951Permalink
(-)-epigallocatechin 3-gallate — accumulates in brain
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“We first demonstrated that EGCG can be detected in plasma and brain tissue using mass spectral analysis.”
Quoted verbatim from Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.. - Study
- animal · not in humans
- Dose
- FontUp 50 mg/kg by oral gavage, morning and evening
- Population
- Male wild-type and TgBACDyrk1A mice given FontUp (EGCG-enriched supplement) by oral gavage
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.2020PMID:32092951Permalink