(-)-epigallocatechin 3-gallate/Finding
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Inhibits DYRK1A
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“As expected, the DYRK1A-ΔC and DYRK1A activities decreased with increasing concentrations of EGCG (Table 1 and Table 2).”
Quoted verbatim from Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.. - Study
- in vitro · not in humans
- Dose
- concentrations up to 100 uM
- Population
- Purified recombinant DYRK1A catalytic domain and native human DYRK1A, in vitro kinase assay with fluorescent peptide substrate and 1 mM ATP
Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup® Dietary Supplement: Role of Green Tea Catechins.2020PMID:32092951Permalink
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To cite this finding: https://catalystproject.ai/e/01M454XJBVRN2N4V0GFX4XFWSR