Papers/PMID:31461895
Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring.
Nutrients2019The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
creatine — increases hippocampal CA1 long-term potentiation magnitude
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Exposure to Cr supplementation during brain development affected LTP in CA1 neurons in adult rats: high-frequency stimulation (HFS) of stratum radiatum induced an intense LTP that increased significantly over time compared to the control group.”
Quoted verbatim from Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- creatine 1 g/100 ml in drinking water to dams, gestation day 11 to day before delivery
- Population
- Adult male Sprague-Dawley rats (postnatal day 60-70) born to dams given creatine in drinking water from gestation day 11 until the day before delivery; hippocampal CA1 slices ex vivo
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