Papers/PMID:30817625
A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.
Medicine2019The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
selenium atom — decreases intensive care unit length of stay
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“The aggregated results of the 6 trials with 1445 patients shown that selenium supplementation was associated with reduced the staying time in ICU (SMD = −0.15, 95% CI: −0.25 to −0.04) with a fixed effect model (I2 = 57%, P =.04) (Fig. S7).”
Quoted verbatim from A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.. - Study
- meta-analysis
- Population
- Patients with sepsis, severe sepsis, septic shock or SIRS in randomised trials of intravenous selenium versus placebo
Effect -0.15 standardised mean difference, 95% CI -0.25 to -0.04
A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.2019PMID:30817625Permalink
What did not
1 finding
selenium atom — no detected effect on duration of mechanical ventilation
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“When data from 5 trials about mechanical ventilation were included, selenium supplementation showed similar effect with placebo (SMD = 0.17, 95% CI: −0.30 to 0.63) using a random effect model (I2 = 80%, P =.0005) (Fig. S6).”
Quoted verbatim from A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.. - Study
- meta-analysis
- Population
- Patients with sepsis, severe sepsis, septic shock or SIRS in randomised trials of intravenous selenium versus placebo
Effect 0.17 standardised mean difference, 95% CI -0.3 to 0.63
A meta-analysis of randomized controlled trials: Efficacy of selenium treatment for sepsis.2019PMID:30817625Permalink