Papers/PMID:30806774
Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling.
European journal of nutrition2020The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
creatine — decreases tumour necrosis factor alpha concentration
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Findingreplicated ×1“Creatine intake promoted lower levels of plasma TNF-α and IL-6 and smaller spleen morphology changes such as reduced size of white pulp and lymphoid follicle compared to tumor-bearing rats.”
Quoted verbatim from Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling.. - Study
- animal · not in humans
- Duration
- 3 weeks
- Population
- Walker-256 tumor-bearing Wistar rats given creatine in drinking water for 21 days (tumor implanted after 11 days), compared with tumor-bearing rats without creatine
Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling.2020PMID:30806774Permalink
creatine — decreases interleukin-6 concentration
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Findingreplicated ×1“Creatine intake promoted lower levels of plasma TNF-α and IL-6 and smaller spleen morphology changes such as reduced size of white pulp and lymphoid follicle compared to tumor-bearing rats.”
Quoted verbatim from Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling.. - Study
- animal · not in humans
- Duration
- 3 weeks
- Population
- Walker-256 tumor-bearing Wistar rats given creatine in drinking water for 21 days (tumor implanted after 11 days), compared with tumor-bearing rats without creatine
Creatine supplementation in Walker-256 tumor-bearing rats prevents skeletal muscle atrophy by attenuating systemic inflammation and protein degradation signaling.2020PMID:30806774Permalink