Papers/PMID:30496228
Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis.
PloS one2018The record
2 findings · 1 compound · 2 endpoints
What it reported
How to read these marksWhat moved
2 findings
all-trans-retinol — decreases hospital length of stay
StrongEvidence strength: strong. Randomised human trials or their synthesis, with the effect's size and interval recorded and no recorded weakness outstanding.Findingreplicated ×3“Kiatchoosakun demonstrated a significant reduction in duration of hospital stay in the vitamin A treatment groups [mean difference (MD), −49.9; 95% CI −88.78 to −11.02; 20 infants].”
Quoted verbatim from Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis.. - Study
- meta-analysis
- Participants
- 20
- Duration
- 4 weeks
- Dose
- 5,000 IU intramuscular three times per week for 4 weeks
- Population
- Extremely low birth weight infants; a single trial (Kiatchoosakun 2014, 20 ELBW infants) was the only study in this analysis, giving vitamin A 5,000 IU intramuscularly three times per week for 4 weeks versus a sham procedure
Effect -49.9 mean difference, 95% CI -88.78 to -11.02
Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis.2018PMID:30496228Permalink
all-trans-retinol — decreases bronchopulmonary dysplasia of any grade at 36 weeks
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1“The meta-analysis supported a reduction in the risk of BPD at the postmenstrual age of 36 weeks in the vitamin A treatment group (RR, 0.88; 95% CI, 0.77–0.99; moderate quality of evidence).”
Quoted verbatim from Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Extremely low birth weight infants (birth weight under 1,000 g) in four randomised trials; vitamin A given intramuscularly in three trials and orally in one, versus sham injection or placebo liquid; oxygen-dependent survivors at 36 weeks postmenstrual age
Effect 0.88 risk ratio, 95% CI 0.77 to 0.99
Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants: a systematic review and meta-analysis.2018PMID:30496228Permalink