Papers/PMID:29720494
Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.
Archives of disease in childhood2018The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
melatonin — increases total sleep time
PreliminaryGrade D, Preliminary. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“A meta-analysis of nine studies (n=541) showed that melatonin significantly improved total sleep time compared with placebo (mean difference (MD)=48.26 min, 95% CI 36.78 to 59.73, I2=31%).”
Quoted verbatim from Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.. - Study
- meta-analysis
- Participants
- 541
- Population
- Children under 18 years with neurodevelopmental disorders enrolled in randomised controlled trials of melatonin versus placebo or other intervention for sleep problems (13 RCTs, n=682 total)
Effect 48.26 mean difference, 95% CI 36.78 to 59.73
Melatonin for the management of sleep problems in children with neurodevelopmental disorders: a systematic review and meta-analysis.2018PMID:29720494Permalink