Papers/PMID:26754058
Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials.
Scientific reports2016The record
3 findings · 1 compound · 3 endpoints · 2 null
What it reported
How to read these marksWhat moved
1 finding
(R)-carnitine — decreases total cholesterol (TC)
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Meta-analysis suggested a significant reduction in plasma concentrations of total cholesterol (WMD: −9.49 mg/dL, 95% CI: −17.07, −1.92, p = 0.014) and a borderline significant trend in reduction of LDL-C (WMD: −4.67 mg/dL, 95% CI: −9.78, 0.45, p = 0.074) following L-carnitine supplementation.”
Quoted verbatim from Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 1 g 3 times per week to 4 g/day across included trials; 1 to 24 weeks
- Population
- Adults in 7 treatment arms of randomised trials (intravenous and oral L-carnitine pooled) reporting total cholesterol, versus control
Effect -9.49 mean difference, 95% CI -17.07 to -1.92
Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials.2016PMID:26754058Industry fundedPermalink
What did not
2 findings
(R)-carnitine — no detected effect on HDL cholesterol
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“However, plasma HDL-C (WMD: 0.85 mg/dL, 95% CI: −2.34, 4.05, p = 0.601) and triglycerides (WMD: −2.42 mg/dL, 95% CI: −34.85, 30.01, p = 0.884) were not altered by L-carnitine.”
Quoted verbatim from Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 1 g 3 times per week to 4 g/day across included trials; 1 to 24 weeks
- Population
- Adults in 6 treatment arms of randomised trials (intravenous and oral L-carnitine pooled) reporting HDL-C, versus control
Effect 0.85 mean difference, 95% CI -2.34 to 4.05
Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials.2016PMID:26754058Industry fundedPermalink
(R)-carnitine — no detected effect on triglycerides
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×1“However, plasma HDL-C (WMD: 0.85 mg/dL, 95% CI: −2.34, 4.05, p = 0.601) and triglycerides (WMD: −2.42 mg/dL, 95% CI: −34.85, 30.01, p = 0.884) were not altered by L-carnitine.”
Quoted verbatim from Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Dose
- 1 g 3 times per week to 4 g/day across included trials; 1 to 24 weeks
- Population
- Adults in 6 treatment arms of randomised trials (intravenous and oral L-carnitine pooled) reporting triglycerides, versus control
Effect -2.42 mean difference, 95% CI -34.85 to 30.01
Impact of L-carnitine on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled trials.2016PMID:26754058Industry fundedPermalink