Papers/PMID:26031193
Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study.
Neurogastroenterology and motility2016The record
1 finding drawn from this paper, on 1 compound across 1 endpoint.
What it reported
How to read these marksWhat moved
1 finding
5-hydroxy-L-tryptophan — increases plasma/serum 5-hydroxytryptophan concentration
PreliminaryGrade D, Preliminary. Non-human or in vitro only.Findingreplicated ×1“Administration of 5-HTP significantly increased plasma 5-HTP levels (p < 0.001), did not affect 5-HT levels (p > 0.05), while levels of the main metabolite of 5-HT, 5-hydroxyindoleacetic acid, increased significantly (p < 0.05) in both groups.”
Quoted verbatim from Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study.. - Study
- RCT
- Dose
- 100 mg, single oral dose
- Population
- 15 IBS patients and 15 healthy volunteers; single 100 mg oral dose of 5-HTP vs placebo
Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study.2016PMID:26031193