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PapersPMID:26031193

Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study.

Neurogastroenterology and motility2016The record ↗

01 · finding
1
02 · compound
1
03 · endpoint
1
04 · null
0
  1. Finding, very limited evidenceraisesPlasma/serum 5-hydroxytryptophan concentration

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1 findingHow to read these marks →

  • 5-hydroxy-L-tryptophan — increases plasma/serum 5-hydroxytryptophan concentration

    very limitedFindingreplicated ×1

    “Administration of 5-HTP significantly increased plasma 5-HTP levels (p < 0.001), did not affect 5-HT levels (p > 0.05), while levels of the main metabolite of 5-HT, 5-hydroxyindoleacetic acid, increased significantly (p < 0.05) in both groups.”
    Quoted verbatim from Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study.
    Study
    RCT
    Dose studied
    100 mg, single oral dose
    Population
    15 IBS patients and 15 healthy volunteers; single 100 mg oral dose of 5-HTP vs placebo

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