html[data-identity='g1'] .g1-header .g1-header-wide .g1-header-layers button { display: none; } html[data-identity='g1'] .g1-header-wide .g1-header-layers a { align-self: center; } html[data-identity='g1'] .g1-header .g1-header-narrow { display: none; } html[data-identity='g1'] .g1-header-nojs { display: none; } @media (width < 721px) { html[data-identity='g1'] .g1-header .g1-header-nojs { display: flex; flex-wrap: wrap; column-gap: 20px; padding: 0 16px 8px; } html[data-identity='g1'] .g1-header-nojs ul { display: flex; gap: 20px; list-style: none; margin: 0; padding: 0; box-shadow: none; } html[data-identity='g1'] .g1-header-nojs a { display: block; padding: 6px 0; font-size: 15px; line-height: 24px; color: var(--ink2); text-decoration: none; } html[data-identity='g1'] .g1-header-nojs a[aria-current='true'] { color: var(--ink); text-decoration: underline 2px var(--ember); text-underline-offset: 6px; } }

PapersPMID:25921948

The effect of histidine on mental fatigue and cognitive performance in subjects with high fatigue and sleep disruption scores.

Physiology & behavior2015The record ↗

L-histidine

lowersSubjective fatigue

What moved

1 findingHow to read these marks →

Decreases subjective fatigue
very limited
“The fatigue T-scores on the POMS test decreased significantly following histidine ingestion compared to placebo ingestion (p<0.05).”
Study
crossover
Duration
14 days
Dose studied
histidine ingested daily for two weeks (dose not stated in abstract)
Population
Adults selected for high fatigue and sleep disruption scores; double-blind crossover against placebo

Study record

Design: crossover trial
Species: human
Population: Subjects with high fatigue and sleep disruption scores
Participants: not reported
Comparator: placebo
Duration: not reported
Endpoints measured: 4