Papers/PMID:24040282
Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?
PloS one2013The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
all-trans-retinol — no detected effect on all-cause mortality
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×2“Vitamin A used singly versus placebo (2 trials, 2406 participants) had no significant effect on mortality (RR 1.18, 95% CI 0.83 to 1.68, I2 = 0%) (Table 4).”
Quoted verbatim from Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?. - Study
- meta-analysis
- Participants
- 2,406
- Dose
- vitamin A singly, 667 to 7500 µg daily
- Population
- Adults in 2 low-risk-of-bias primary or secondary prevention randomised trials of vitamin A given alone versus placebo; all-cause mortality at maximum follow-up
Effect 1.18 risk ratio, 95% CI 0.83 to 1.68
Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?2013PMID:24040282Permalink