Papers/PMID:23343189
Meta-analysis of randomized controlled trials on magnesium in addition to beta-blocker for prevention of postoperative atrial arrhythmias after coronary artery bypass grafting.
BMC cardiovascular disorders2013The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
magnesium(2+) — no detected effect on all-cause mortality
SuggestiveGrade C, Suggestive. Human evidence with several recorded weaknesses, or a design that tops out at C.FindingNull result“Overall mortality was not significantly affected by magnesium in addition to beta-blocker (OR 0.59, 95% CI 0.08-4.56, P = 0.62).”
Quoted verbatim from Meta-analysis of randomized controlled trials on magnesium in addition to beta-blocker for prevention of postoperative atrial arrhythmias after coronary artery bypass grafting.. - Study
- meta-analysis
- Dose
- IV bolus or continuous infusion, total dose beyond 35 mmol, given prophylactically before onset of arrhythmia; pooled across 5 trials with varying regimens
- Population
- Adults undergoing coronary artery bypass grafting in sinus rhythm preoperatively, given magnesium in addition to beta-blocker versus beta-blocker alone (beta-blocker constant background in both arms); postoperative mortality, 3 trials, 454 patients
Effect 0.59 odds ratio, 95% CI 0.08 to 4.56
Meta-analysis of randomized controlled trials on magnesium in addition to beta-blocker for prevention of postoperative atrial arrhythmias after coronary artery bypass grafting.2013PMID:23343189Permalink