Papers/PMID:22742601
Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.
Paediatric and perinatal epidemiology2012The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
all-trans-retinol — increases blood haemoglobin concentration
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“Average follow-up measures of mean hemoglobin assessed after supplementation during pregnancy were found to be significantly higher among women supplemented with VA by 0.35 g/dL [95% CI 0.24, 0.45] (Supplementary Figure 9) and a change in 0.19 g/dL [95% CI 0.06, 0.33] among studies reporting change in hemoglobin levels (Supplementary Figure 10).”
Quoted verbatim from Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- 3333 to 10,000 IU vitamin A daily-equivalent, varying across trials
- Population
- Pregnant women in pooled randomised trials of vitamin A supplementation during pregnancy (mean hemoglobin at follow-up during pregnancy)
Effect 0.35 mean difference, 95% CI 0.24 to 0.45
Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.2012PMID:22742601Permalink
What did not
1 finding
all-trans-retinol — no detected effect on preterm birth incidence
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×3“No significant overall effect was found of VA on preterm birth (<37 weeks) or early preterm birth (<34 weeks).”
Quoted verbatim from Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- 3333 to 10,000 IU vitamin A daily-equivalent, varying across trials
- Population
- Pregnant women in pooled randomised trials of vitamin A supplementation during pregnancy, overall estimate including trials in HIV-positive women
Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.2012PMID:22742601Permalink