Papers/PMID:21249656
Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.
The Cochrane database of systematic reviews2011The record
2 findings · 1 compound · 2 endpoints · 1 null
What it reported
How to read these marksWhat moved
1 finding
all-trans-retinol — increases birth weight
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“However, antenatal vitamin A supplementation significantly improved birth weight (3 trials, 1809 women: MD 89.78, 95%CI 84.73 to 94.83; I(2)=33.0%), but there was no evidence of an effect on preterm births (3 trials, 2110 women: RR 0.88, 95%CI 0.65 to 1.19; I(2)=58.1%), stillbirths (4 trials, 2855 women: RR 0.99, 95%CI 0.68 to 1.43; I(2)=0%), deaths by 24 months (2 trials, 1635 women: RR 1.03, 95%CI 0.88 to 1.20; I(2)=0%), postpartum CD4 levels (1 trial, 727 women: MD -4.00, 95% CI -51.06 to 43.06), and maternal death ( 1 trial, 728 women: RR 0.49, 95%CI 0.04 to 5.37).”
Quoted verbatim from Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.. - Study
- meta-analysis
- Participants
- 1,809
- Population
- HIV-infected pregnant women; meta-analysis of randomised trials of antenatal vitamin A supplementation against placebo
Effect 89.78 mean difference, 95% CI 84.73 to 94.83
Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.2011PMID:21249656Permalink
What did not
1 finding
all-trans-retinol — no detected effect on preterm birth incidence
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×3“However, antenatal vitamin A supplementation significantly improved birth weight (3 trials, 1809 women: MD 89.78, 95%CI 84.73 to 94.83; I(2)=33.0%), but there was no evidence of an effect on preterm births (3 trials, 2110 women: RR 0.88, 95%CI 0.65 to 1.19; I(2)=58.1%), stillbirths (4 trials, 2855 women: RR 0.99, 95%CI 0.68 to 1.43; I(2)=0%), deaths by 24 months (2 trials, 1635 women: RR 1.03, 95%CI 0.88 to 1.20; I(2)=0%), postpartum CD4 levels (1 trial, 727 women: MD -4.00, 95% CI -51.06 to 43.06), and maternal death ( 1 trial, 728 women: RR 0.49, 95%CI 0.04 to 5.37).”
Quoted verbatim from Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.. - Study
- meta-analysis
- Participants
- 2,110
- Population
- HIV-infected pregnant women; meta-analysis of randomised trials of antenatal vitamin A supplementation against placebo
Effect 0.88 risk ratio, 95% CI 0.65 to 1.19
Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection.2011PMID:21249656Permalink