Papers/PMID:20427778
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.
The New England journal of medicine2010The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
α-tocopherol — no detected effect on health-related quality of life
Evidence strength: moderate.FindingNull result“Changes in quality of life, as assessed by the scores for both the mental and physical components of the SF-36, did not differ significantly between the vitamin E group or the pioglitazone group and the placebo group (Table 3).”
Quoted verbatim from Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.. - Study
- RCT
- Duration
- 22 months
- Dose
- 800 IU RRR-alpha-tocopherol (natural form) once daily for 96 weeks, with a pioglitazone-like placebo
- Population
- Adults with nonalcoholic steatohepatitis and without diabetes; vitamin E group against placebo, with a separate pioglitazone arm in the same trial; SF-36 mental and physical components
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis.2010PMID:2042777810.1056/NEJMoa0907929Industry fundedPermalink