Papers/PMID:19421321
Lack of functional benefit with glutamine versus placebo in Duchenne muscular dystrophy: a randomized crossover trial.
PloS one2009The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
L-glutamine — no detected effect on serum creatine kinase activity
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Consistent with muscle mass, markers of myofibrillar protein breakdown (3 methyl-histidine/creatinine ratio in urine) and serum CPK were not affected by Gln treatment compared with placebo (Table 2).”
Quoted verbatim from Lack of functional benefit with glutamine versus placebo in Duchenne muscular dystrophy: a randomized crossover trial.. - Study
- crossover
- Dose
- 0.5 g/kg/d oral glutamine once daily for 4 months versus maltodextrin placebo of equal weight, 1-month washout
- Population
- 30 ambulant boys aged 2 to 10 years with Duchenne muscular dystrophy, 5 on corticosteroids; change over the 4-month glutamine phase versus the 4-month placebo phase
Lack of functional benefit with glutamine versus placebo in Duchenne muscular dystrophy: a randomized crossover trial.2009PMID:19421321Permalink