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PapersPMID:18448585

Mechanism of urinary calcium regulation by urinary magnesium and pH.

Journal of the American Society of Nephrology2008The record ↗

magnesium(2+)

lowersTRPV5

What moved

1 findingHow to read these marks →

Inhibits TRPV5
insufficient
“Calcium uptake by TRPV5 was directly inhibited by magnesium and low pH.”
Study
in vitro · not in humans
Population
TRPV5 expressed in Xenopus oocytes

Study record

Design: mechanistic study / other
Species: mixed
Population: 17 clinical trials with pharmacologically manipulated urinary magnesium/pH (regression analysis); rats given intravenous calcium chloride, magnesium chloride or vehicle, with and without parathyroidectomy or furosemide; TRPV5 expressed in Xenopus oocytes
Participants: not reported
Comparator: placebo
Duration: not reported
Endpoints measured: 6