Papers/PMID:12814711
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials.
Lancet (London, England)2003The record
1 finding · 1 compound · 1 endpoint · 1 null
What it reported
How to read these marksEvery finding here is a null result.
What did not
1 finding
α-tocopherol — no detected effect on all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×4“Vitamin E did not provide benefit in mortality compared with control treatment (11.3 vs 11.1%, odds ratio 1.02 [95% CI 0.98-1.06] p=0.42) or significantly decrease risk of cardiovascular death (6.0 vs 6.0%, p=0.86) or cerebrovascular accident (3.6 vs 3.5%, p=0.31).”
Quoted verbatim from Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials.. - Study
- meta-analysis
- Dose
- 50-800 IU across trials
- Population
- Participants in seven randomised trials of vitamin E (50-800 IU), each with 1000 or more patients
Effect 1.02 odds ratio, 95% CI 0.98 to 1.06
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