Papers/PMID:10048684
A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania.
The Pediatric infectious disease journal1999The record
1 finding · 1 compound · 1 endpoint
What it reported
How to read these marksWhat moved
1 finding
all-trans-retinol — decreases all-cause mortality
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×10“Overall vitamin A supplements resulted in a 49% reduction in mortality [relative risk (RR), 0.51; 95% confidence interval (CI), 0.29 to 0.90, P = 0.02].”
Quoted verbatim from A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania.. - Study
- RCT
- Dose
- 400 000 IU (half for infants) at baseline and again 4 and 8 months after discharge, versus placebo, added to standard pneumonia treatment
- Population
- Tanzanian children aged 6 months to 5 years admitted to hospital with pneumonia, HIV-infected and uninfected combined; severely malnourished children and those with clinical vitamin A deficiency excluded
Effect 0.51 risk ratio, 95% CI 0.29 to 0.9
A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania.1999PMID:10048684Permalink