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Subsystem: Vitamin E metabolism Remove
1–50 of 51 reactions in Vitamin E metabolism
alpha-tocopheryl quinone[c] + H+[c] + NADPH[c] = alpha-tocopheryl hydroquinone[c] + NADP+[c]
Left to rightBalancedHuman-GEM MAR03047
H2O[c] + 7,8-Epoxy-8Alpha-Hydroperoxytocopherone[c] = H2O2[c] + 5,6-Epoxy-Alpha-Tocopheryl Quinone[c]
ReversibleBalancedEC 1.14.14.1Human-GEM MAR03049
H2O[c] + 4Alpha,5-Epoxy-8Alpha-Hydroperoxytocopherone[c] = H2O2[c] + 2,3-Epoxy-Alpha-Tocopheryl Quinone[c]
ReversibleBalancedHuman-GEM MAR03050
gamma-tocopheroxyl-radical[c] + H2O[c] = 8alpha-hydroxy-gamma-tocopherone[c] + H+[c]
ReversibleUnbalancedEC 1.3.3.6Human-GEM MAR04007
alpha-tocotrienol[c] + monodehydroascorbate[c] = alpha-tocotrienoxyl radical[c] + ascorbate[c]
Reversible
alpha-tocotrienol[c] + H+[c] + NADPH[c] + O2[c] = 13-hydroxy-alpha-tocotrienol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06426
alpha-tocotrienol[r] + H+[r] + NADPH[r] + O2[r] = 13-hydroxy-alpha-tocotrienol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06427
13-hydroxy-alpha-tocotrienol[c] + H+[c] + 2 NADPH[c] + 2 O2[c] = 13-carboxy-alpha-tocotrienol[c] + 3 H2O[c] + 2 NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06428
13-hydroxy-alpha-tocotrienol[r] + H+[r] + 2 NADPH[r] + 2 O2[r] = 13-carboxy-alpha-tocotrienol[r] + 3 H2O[r] + 2 NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06429
13-carboxy-alpha-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] = 11-carboxy-alpha-tocotrienol[m] + AMP[m] + 2 H+[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06432
11-carboxy-alpha-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 9-carboxy-alpha-tocotrienol[m] + acetyl-CoA[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m]
Left to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-Human-GEM MAR06433
9-carboxy-alpha-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] = 7-carboxy-alpha-tocotrienol[m] + AMP[m] + 2 H+[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedHuman-GEM MAR06434
7-carboxy-alpha-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + O2[m] = 5-carboxy-alpha-chromanol[m] + acetyl-CoA[m] + AMP[m] + H+[m] + H2O2[m] + PPi[m]
Left to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-Human-GEM MAR06435
5-carboxy-alpha-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 3-carboxy-alpha-chromanol[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06436
gamma-tocotrienol[c] + H+[c] + NADPH[c] + O2[c] = 13-hydroxy-gamma-tocotrienol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06441
gamma-tocotrienol[r] + H+[r] + NADPH[r] + O2[r] = 13-hydroxy-gamma-tocotrienol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06442
13-hydroxy-gamma-tocotrienol[c] + H+[c] + 2 NADPH[c] + 2 O2[c] = 13-carboxy-gamma-tocotrienol[c] + 3 H2O[c] + 2 NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06443
13-hydroxy-gamma-tocotrienol[r] + H+[r] + 2 NADPH[r] + 2 O2[r] = 13-carboxy-gamma-tocotrienol[r] + 3 H2O[r] + 2 NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06444
13-carboxy-gamma-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] = 11-carboxy-gamma-tocotrienol[m] + AMP[m] + 2 H+[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedHuman-GEM MAR06447
11-carboxy-gamma-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 9-carboxy-gamma-tocotrienol[m] + acetyl-CoA[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m]
Left to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-Human-GEM MAR06448
9-carboxy-gamma-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] = 7-carboxy-gamma-tocotrienol[m] + AMP[m] + 2 H+[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06450
7-carboxy-gamma-tocotrienol[m] + ATP[m] + CoA[m] + 2 H2O[m] + O2[m] = 5-carboxy-gamma-chromanol[m] + acetyl-CoA[m] + AMP[m] + H+[m] + H2O2[m] + PPi[m]
Left to rightBalancedEC 1.1.1.35, 1.3.1.34, 1.3.3.6, 2.3.1.16, 3.1.2.2, 3.1.2.27, 4.2.1.17, 5.1.99.4, 5.3.3.8, 6.2.1.-Human-GEM MAR06451
5-carboxy-gamma-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = AMP[m] + gamma-carboxyethyl-hydroxychroman[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06453
gamma-tocopheroxyl-radical[c] + H+[c] = gamma-tocopherol[c]
ReversibleUnbalancedHuman-GEM MAR06456
8alpha-hydroxy-gamma-tocopherone[c] = gamma-tocopheroxyl-radical[c] + hydroxide[c]
ReversibleUnbalancedHuman-GEM MAR06457
8alpha-hydroxy-gamma-tocopherone[c] = gamma-tocopheryl-quinone[c]
ReversibleBalancedHuman-GEM MAR06458
5-nitro-gamma-tocopherol[c] = gamma-tocopheroxyl-radical[c] + nitrite[c]
ReversibleUnbalancedHuman-GEM MAR06459
5-nitro-gamma-tocopherol[c] + H2O[c] = gamma-tocopherol[c] + H+[c] + peroxynitrite[c]
ReversibleBalancedHuman-GEM MAR06460
nitrosoperoxycarbonate[c] = CO2[c] + peroxynitrite[c]
Left to rightBalancedHuman-GEM MAR06461
gamma-tocopherol[c] + H+[c] + NADPH[c] + O2[c] = 13-hydroxy-gamma-tocopherol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06464
gamma-tocopherol[r] + H+[r] + NADPH[r] + O2[r] = 13-hydroxy-gamma-tocopherol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06465
13-hydroxy-gamma-tocopherol[c] + H+[c] + 2 NADPH[c] + 2 O2[c] = 13-carboxy-gamma-tocopherol[c] + 3 H2O[c] + 2 NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06466
13-hydroxy-gamma-tocopherol[r] + H+[r] + 2 NADPH[r] + 2 O2[r] = 13-carboxy-gamma-tocopherol[r] + 3 H2O[r] + 2 NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06467
13-carboxy-gamma-tocopherol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 11-carboxy-gamma-chromanol[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedHuman-GEM MAR06470
11-carboxy-gamma-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 9-carboxy-gamma-chromanol[m] + acetyl-CoA[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06471
9-carboxy-gamma-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 7-carboxy-gamma-chromanol[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06472
7-carboxy-gamma-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 5-carboxy-gamma-chromanol[m] + acetyl-CoA[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06473
alpha-tocopherol[c] + H+[c] + NADPH[c] + O2[c] = 13-hydroxy-alpha-tocopherol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06476
alpha-tocopherol[r] + H+[r] + NADPH[r] + O2[r] = 13-hydroxy-alpha-tocopherol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06477
13-hydroxy-alpha-tocopherol[c] + H+[c] + 2 NADPH[c] + 2 O2[c] = 13-carboxy-alpha-tocopherol[c] + 3 H2O[c] + 2 NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06478
13-hydroxy-alpha-tocopherol[r] + H+[r] + 2 NADPH[r] + 2 O2[r] = 13-carboxy-alpha-tocopherol[r] + 3 H2O[r] + 2 NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR06479
13-carboxy-alpha-tocopherol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 11-carboxy-alpha-chromanol[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedHuman-GEM MAR06482
11-carboxy-alpha-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 9-carboxy-alpha-chromanol[m] + acetyl-CoA[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06484
9-carboxy-alpha-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 7-carboxy-alpha-chromanol[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m] + propanoyl-CoA[m]
Left to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-Human-GEM MAR06486
7-carboxy-alpha-chromanol[m] + ATP[m] + CoA[m] + 2 H2O[m] + NAD+[m] + O2[m] = 5-carboxy-alpha-chromanol[m] + acetyl-CoA[m] + AMP[m] + 2 H+[m] + H2O2[m] + NADH[m] + PPi[m]
Left to rightBalancedHuman-GEM MAR06488
gamma-carboxyethyl-hydroxychroman[c] + UDP-glucuronate[c] = gamma-CEHC-glucuronide[c] + UDP[c]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR06490
gamma-CEHC-glucuronide[c] + H2O[c] = gamma-carboxyethyl-hydroxychroman[c] + glucuronate[c] + H+[c]
ReversibleBalancedEC 3.2.1.31Human-GEM MAR06492
3-carboxy-alpha-chromanol[c] + UDP-glucuronate[c] = alpha-CEHC-glucuronide[c] + UDP[c]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR06495
alpha-CEHC-glucuronide[c] + H2O[c] = 3-carboxy-alpha-chromanol[c] + glucuronate[c] + H+[c]
Left to rightBalancedEC 3.2.1.31Human-GEM MAR06496
alpha-tocopheryl quinone[c] + 5 H+[m] + NADH[m] = alpha-tocopheryl hydroquinone[c] + 4 H+[i] + NAD+[m]
Left to rightBalancedTransportEC 7.1.1.2Human-GEM MAR06500