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Subsystem: Phenylalanine, tyrosine and tryptophan biosynthesis Remove
1–50 of 157 reactions in Phenylalanine, tyrosine and tryptophan biosynthesis
CoA[m] + H+[m] + N-arachidonoylglycine[m] = arachidonyl-CoA[m] + glycine[m]
ReversibleBalancedEC 2.3.1.13Human-GEM MAR03743
O2[c] + tryptophan[c] = L-formylkynurenine[c]
Left to rightBalancedEC 1.13.11.11, 1.13.11.52Human-GEM MAR04214
H2O[c] + L-formylkynurenine[c] = formate[c] + H+[c] + kynurenine[c]
Left to rightBalancedEC 3.5.1.49, 3.5.1.9Human-GEM MAR04216
H2O[c] + L-formylkynurenine[c] = alanine[c] + formylanthranilate[c] + H+[c]
Left to rightBalancedEC 3.7.1.3Human-GEM MAR04218
formylanthranilate[c] + H2O[c] = anthranilate[c] + formate[c] + H+[c]
Left to rightBalanced
3-hydroxy-L-kynurenine[c] + H2O[c] + NADP+[c] = H+[c] + kynurenine[c] + NADPH[c] + O2[c]
ReversibleBalancedEC 1.14.13.9Human-GEM MAR04220
AKG[c] + kynurenine[c] = 4-hydroxy-2-quinolinecarboxylic acid[c] + glutamate[c] + H2O[c]
Left to rightBalancedEC 2.6.1.7Human-GEM MAR04222
H2O[c] + kynurenine[c] = alanine[c] + anthranilate[c] + H+[c]
Left to rightBalancedEC 3.7.1.3Human-GEM MAR04224
3-hydroxy-L-kynurenine[c] + H2O[c] = 3-hydroxyanthranilate[c] + alanine[c]
Left to rightBalancedEC 3.7.1.3Human-GEM MAR04225
2 3-hydroxyanthranilate[c] + 4 O2[c] = cinnavalininate[c] + 4 H+[c] + 2 H2O2[c] + 2 O2-[c]
Left to rightBalancedEC 1.11.1.6Human-GEM MAR04227
2-amino-3-carboxymuconate semialdehyde[c] + H+[c] = 2-aminomuconate semialdehyde[c] + CO2[c]
Left to rightBalancedEC 4.1.1.45Human-GEM MAR04231
2-aminomuconate semialdehyde[c] = H+[c] + H2O[c] + picolinic acid[c]
ReversibleBalancedHuman-GEM MAR04232
2-aminomuconate semialdehyde[c] + H2O[c] + NAD+[c] = 2-aminomuconate[c] + 2 H+[c] + NADH[c]
Left to rightBalancedEC 1.2.1.32Human-GEM MAR04233
2-aminomuconate[c] + H2O[c] + NADPH[c] = 2-oxoadipate[c] + NADP+[c] + NH3[c]
Left to rightBalancedEC 1.5.1.-Human-GEM MAR04235
FAD[m] + glutaryl-CoA[m] + H+[m] = CO2[m] + crotonyl-CoA[m] + FADH2[m]
Left to rightBalancedEC 1.3.8.6Human-GEM MAR04243
3-hydroxy-L-kynurenine[c] + AKG[c] = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate[c] + glutamate[c]
Left to rightBalancedEC 2.6.1.7Human-GEM MAR04244
4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate[c] = H2O[c] + xanthurenate[c]
Left to rightBalancedHuman-GEM MAR04245
3-hydroxy-L-kynurenine[c] + AKG[c] = glutamate[c] + H2O[c] + xanthurenate[c]
ReversibleBalancedEC 2.6.1.7Human-GEM MAR04246
H+[c] + oxo-xanthurenate[c] = xanthurenate[c]
ReversibleBalancedHuman-GEM MAR04248
H+[c] + tryptophan[c] = CO2[c] + tryptamine[c]
Left to rightBalancedEC 4.1.1.28Human-GEM MAR06707
1-(1,2,3,4,5-pentahydroxypent-1-yl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylate[c] + H2O[c] = mannose[c] + tryptophan[c]
ReversibleBalancedHuman-GEM MAR06708
beta-carboline[c] + 2 H2O[c] = tryptophan[c]
ReversibleBalancedHuman-GEM MAR06709
SAM[c] + tryptamine[c] = H+[c] + N-methyltryptamine[c] + SAH[c]
Left to rightBalancedEC 2.1.1.49Human-GEM MAR06711
1,2,3,4-tetrahydro-beta-carboline[c] + H2O[c] = formaldehyde[c] + tryptamine[c]
ReversibleBalancedHuman-GEM MAR06712
H2O[c] + O2[c] + tryptamine[c] = H+[c] + H2O2[c] + indole-3-acetaldehyde[c] + NH3[c]
Left to rightBalancedEC 1.4.3.4, 1.4.3.22Human-GEM MAR06713
H2O[c] + indole-3-acetaldehyde[c] + NAD+[c] = 2 H+[c] + indoleacetate[c] + NADH[c]
Left to rightBalancedEC 1.2.1.3Human-GEM MAR06714
indoleacetate[c] + SAM[c] = methyl-indole-3-acetate[c] + SAH[c]
Left to rightBalancedEC 2.1.1.6Human-GEM MAR06715
5-hydroxy-L-tryptophan[c] + O2[c] = 5-hydroxy-N-formylkynurenine[c]
Left to rightBalancedEC 1.13.11.52Human-GEM MAR06716
5-hydroxy-N-formylkynurenine[c] + H2O[c] = 5-hydroxykynurenine[c] + formate[c] + H+[c]
Left to rightBalancedEC 3.5.1.9Human-GEM MAR06717
5-hydroxykynurenine[c] + H+[c] = 5-hydroxykynurenamine[c] + CO2[c]
Left to rightBalancedEC 4.1.1.28Human-GEM MAR06718
5-hydroxykynurenamine[c] + O2[c] = 4,6-dihydroxyquinoline[c] + H+[c] + H2O2[c] + NH3[c]
Left to rightBalancedEC 1.4.3.4Human-GEM MAR06719
2 H+[c] + kynurenine[c] + UDP-glucuronate[c] = 3-hydroxykynurenine-O-beta-D-glucoside[c] + UDP[c]
Left to rightUnbalancedHuman-GEM MAR06720
3-hydroxykynurenine-O-beta-D-glucoside[c] + NADH[c] = 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid-O-glucoside[c] + NAD+[c] + NH3[c]
Left to rightBalancedEC 3.5.4.-Human-GEM MAR06721
3-hydroxykynurenine-O-beta-D-glucoside[c] + AKG[c] = glutamate[c] + H2O[c] + xanthurenate-8-O-beta-D-glucoside[c]
ReversibleBalancedEC 2.6.1.-Human-GEM MAR06722
3-hydroxykynurenine-O-beta-D-glucoside[c] + GSH[c] = glutathionyl-3-hydroxykynurenine glucoside[c] + H2O[c]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR06723
AKG[c] + phenylalanine[c] = glutamate[c] + phenylpyruvate[c]
ReversibleBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57Human-GEM MAR06725
O2[c] + phenylpyruvate[c] = 2-hydroxyphenylacetate[c] + CO2[c]
Left to rightBalancedEC 1.13.11.27Human-GEM MAR06726
phenylpyruvate[c] = 2-hydroxy-3-phenylpropenoate[c]
Left to rightBalancedEC 5.3.2.1Human-GEM MAR06727
O2[c] + tetrahydrobiopterin[c] + tyrosine[c] = dihydrobiopterin[c] + H2O[c] + L-dopa[c]
Left to rightBalancedEC 1.14.16.2Human-GEM MAR06728
2 H+[c] + O2[c] + tyrosine[c] = H2O[c] + L-dopa[c]
Left to rightUnbalancedEC 1.14.18.1Human-GEM MAR06729
L-dopa[c] + SAM[c] = 3-O-methyldopa[c] + H+[c] + SAH[c]
Left to rightBalancedEC 2.1.1.6Human-GEM MAR06730
H+[c] + L-dopa[c] = CO2[c] + dopamine[c]
Left to rightBalancedEC 4.1.1.28Human-GEM MAR06731
H2O[c] + salsolinol[c] = acetaldehyde[c] + dopamine[c]
ReversibleBalancedHuman-GEM MAR06734
salsolinol[c] + SAM[c] = H+[c] + SAH[c] + salsoline[c]
Left to rightBalancedEC 2.1.1.6Human-GEM MAR06735
salsolinol[c] + SAM[c] = H+[c] + N-methylsalsolinol[c] + SAH[c]
Left to rightBalancedEC 2.1.1.6Human-GEM MAR06736
H2O[c] + salsolinol-1-carboxylate[c] = dopamine[c] + pyruvate[c]
ReversibleBalancedHuman-GEM MAR06738
salsolinol-1-carboxylate[c] + SAM[c] = H+[c] + SAH[c] + salsoline-1-carboxylate[c]
Left to rightBalancedEC 2.1.1.6Human-GEM MAR06739
salsolinol-1-carboxylate[c] = 1,2-dehydrosalsolinol[c] + CO2[c] + 2 H+[c]
Left to rightUnbalancedEC 4.1.1.28Human-GEM MAR06740
ascorbate[c] + dopamine[c] + O2[c] = dehydroascorbic acid[c] + H2O[c] + noradrenaline[c]
Left to rightBalancedEC 1.14.17.1Human-GEM MAR06741
4,6,7-trihydroxy-1,2,3,4-tetrahydroisoquinoline[c] + H2O[c] = formaldehyde[c] + noradrenaline[c]
ReversibleBalancedHuman-GEM MAR06742