Reactions

Reactions

4 reactions in Lipoic acid metabolism

• dihydrolipoamide dehydrogenase (lipoic acid)

  H+[c] + lipoic acid[c] + NADH[c] = dihydrolipoate[c] + NAD+[c]

  ⇌ ReversibleBalancedEC 1.8.1.4Human-GEM MAR06397

• octanoyl-[acp]:protein N6-octanoyltransferase

  octanoyl-[ACP][m] = [protein]-N6-(octanoyl)lysine[m] + mitoACP[m]

  → Left to rightBalance undeterminableEC 2.3.1.181Human-GEM MAR06402

• lipoyl synthase

  [protein]-N6-(octanoyl)lysine[m] + 3 H+[m] + NADPH[m] + 2 SAM[m] + 4Fe4S iron-sulfur cluster[m] = [protein]-N6-(dihydrolipoyl)lysine[c] + 2 5-deoxyadenosine[m] + 4 Fe2+[m] + 2 H2S[m] + 2 methionine[m] + NADP+[m]

  → Left to rightBalancedEC 2.8.1.8Human-GEM MAR06403

• protein N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase

  [protein]-N6-(lipoyl)lysine[m] + H+[m] + NADH[m] = [protein]-N6-(dihydrolipoyl)lysine[c] + NAD+[m]

  ⇌ ReversibleBalancedEC 1.8.1.4Human-GEM MAR06404