Reactions

Reactions

9 reactions in C5-branched dibasic acid metabolism

• Itaconate:CoA ligase (GDP-forming)

  CoA[m] + GTP[m] + itaconate[m] = GDP[m] + itaconyl-CoA[m] + Pi[m]

  ⇌ ReversibleBalancedEC 6.2.1.5Human-GEM MAR08662

• Itaconate:CoA ligase (ADP-forming)

  ADP[m] + itaconyl-CoA[m] + Pi[m] = ATP[m] + CoA[m] + itaconate[m]

  ⇌ ReversibleBalancedEC 6.2.1.5Human-GEM MAR08663

• (3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)

  H2O[m] + itaconyl-CoA[m] = (3S)-citramalyl-CoA[m]

  → Left to rightBalancedEC 4.2.1.56Human-GEM MAR08664

• itaconyl-CoA hydratase ((3S)-citramalyl-CoA)

  (3S)-citramalyl-CoA[m] = H2O[m] + mesaconyl-CoA[m]

  ⇌ ReversibleBalancedEC 4.2.1.56Human-GEM MAR08665

• (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)

  (3S)-citramalyl-CoA[m] = acetyl-CoA[m] + pyruvate[m]

  → Left to rightBalancedEC 4.1.3.25Human-GEM MAR08666