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Subsystem: Arginine and proline metabolism Remove
1–50 of 99 reactions in Arginine and proline metabolism
2,3-diketo-5-methylthiopentyl-1-phosphate[c] + H2O[c] + O2[c] = 4-methylthio-2-oxobutanoic acid[c] + formate[c] + 2 H+[c] + Pi[c]
Left to rightBalancedHuman-GEM MAR00251
D-proline[x] + FAD[x] = 1-pyrroline-2-carboxylate[x] + FADH2[x] + H+[x]
Left to rightBalancedEC 1.4.3.3Human-GEM MAR00442
H2O[m] + N4-acetylaminobutanal[m] + NAD+[m] = 4-acetamidobutanoate[m] + 2 H+[m] + NADH[m]
Left to rightBalancedEC 1.2.1.88Human-GEM MAR01523
AKG[r] + O2[r] + proline[r] = CO2[r] + succinate[r] + trans-4-hydroxy-L-proline[r]
Left to rightBalancedEC 1.14.11.2Human-GEM MAR01649
arginine[c] + 2 NADPH[c] + 2 O2[c] = citrulline[c] + 2 H2O[c] + 2 NADP+[c] + NO[c]
Left to right
glutamate[m] + 2 H+[m] + NADH[m] = H2O[m] + L-glutamate 5-semialdehyde[m] + NAD+[m]
ReversibleBalancedEC 1.2.1.88Human-GEM MAR03806
AKG[m] + ornithine[m] = glutamate[m] + L-glutamate 5-semialdehyde[m]
ReversibleBalancedEC 2.6.1.13Human-GEM MAR03807
citrulline[m] + H+[m] + Pi[m] = carbamoyl-phosphate[m] + ornithine[m]
ReversibleBalancedEC 2.1.3.3Human-GEM MAR03809
arginine[c] + H2O[c] = ornithine[c] + urea[c]
Left to rightBalancedEC 3.5.3.1Human-GEM MAR03816
1-pyrroline-5-carboxylate[c] + H+[c] + H2O[c] = L-glutamate 5-semialdehyde[c]
ReversibleBalancedEC 1.2.1.88Human-GEM MAR03819
1-pyrroline-5-carboxylate[m] + H+[m] + H2O[m] = L-glutamate 5-semialdehyde[m]
ReversibleBalancedEC 1.2.1.88Human-GEM MAR03820
arginine[c] + H2O[c] = citrulline[c] + H+[c] + NH3[c]
Left to rightBalancedEC 3.5.3.6Human-GEM MAR03832
1-pyrroline-5-carboxylate[c] + 2 H+[c] + NADPH[c] = NADP+[c] + proline[c]
Left to rightBalancedEC 1.5.1.2Human-GEM MAR03833
1-pyrroline-5-carboxylate[c] + 2 H+[c] + NADH[c] = NAD+[c] + proline[c]
Left to rightBalancedEC 1.5.1.2Human-GEM MAR03835
1-pyrroline-5-carboxylate[m] + 2 H+[m] + NADH[m] = NAD+[m] + proline[m]
Left to rightBalancedEC 1.5.1.2Human-GEM MAR03837
ATP[m] + glutamate[m] = ADP[m] + glutamyl-5-phosphate[m]
Left to rightBalancedEC 2.7.2.11Human-GEM MAR03895
glutamyl-5-phosphate[m] + H+[m] + NADPH[m] = L-glutamate 5-semialdehyde[m] + NADP+[m] + Pi[m]
Left to rightBalancedEC 1.2.1.41Human-GEM MAR03897
CO2[m] + H2O[m] = H+[m] + HCO3-[m]
ReversibleBalancedEC 4.2.1.1Human-GEM MAR03956
2 N-(omega)-hydroxyarginine[c] + NADPH[c] + 2 O2[c] = 2 citrulline[c] + H+[c] + 2 H2O[c] + NADP+[c] + 2 NO[c]
Left to rightBalancedEC 1.14.13.39Human-GEM MAR03993
H+[c] + SAM[c] = CO2[c] + S-adenosylmethioninamine[c]
Left to rightBalancedEC 4.1.1.50Human-GEM MAR04073
putrescine[c] + S-adenosylmethioninamine[c] = 5-methylthioadenosine[c] + H+[c] + spermidine[c]
Left to rightBalancedEC 2.5.1.16Human-GEM MAR04075
S-adenosylmethioninamine[c] + spermidine[c] = 5-methylthioadenosine[c] + H+[c] + spermine[c]
Left to rightBalancedEC 2.5.1.16, 2.5.1.22Human-GEM MAR04077
arginine[c] + H+[c] + NADPH[c] + O2[c] = H2O[c] + N-(omega)-hydroxyarginine[c] + NADP+[c]
ReversibleBalancedEC 1.14.13.39Human-GEM MAR04190
arginine[m] + H+[m] = agmatine[m] + CO2[m]
Left to rightBalancedEC 4.1.1.19Human-GEM MAR04191
H+[c] + ornithine[c] = CO2[c] + putrescine[c]
Left to rightBalancedEC 4.1.1.17Human-GEM MAR04212
H+[e] + ornithine[e] = CO2[e] + putrescine[e]
Left to rightBalancedEC 4.1.1.17Human-GEM MAR04422
H2O[e] + O2[e] + putrescine[e] = 4-aminobutanal[e] + H+[e] + H2O2[e] + NH3[e]
Left to rightBalancedEC 1.4.3.10, 1.4.3.21, 1.4.3.22Human-GEM MAR04423
agmatine[m] + H2O[m] = putrescine[m] + urea[m]
Left to rightBalancedEC 3.5.3.11Human-GEM MAR04424
creatine[c] + H+[c] + SAH[c] = guanidinoacetate[c] + SAM[c]
ReversibleBalancedEC 2.1.1.2Human-GEM MAR04583
4-aminobutanal[m] + H2O[m] + NADP+[m] = 4-aminobutyrate[m] + 2 H+[m] + NADPH[m]
Left to rightBalancedEC 1.2.1.3Human-GEM MAR04605
AKG[c] + O2[c] + proline[c] = CO2[c] + succinate[c] + trans-4-hydroxy-L-proline[c]
Left to rightBalancedEC 1.14.11.2Human-GEM MAR04776
AKG[m] + O2[m] + proline[m] = CO2[m] + succinate[m] + trans-4-hydroxy-L-proline[m]
Left to rightBalancedEC 1.14.11.2Human-GEM MAR04777
NAD+[c] + trans-4-hydroxy-L-proline[c] = 2 H+[c] + L-1-pyrroline-3-hydroxy-5-carboxylate[c] + NADH[c]
Left to rightBalancedEC 1.5.1.2Human-GEM MAR04778
NAD+[m] + trans-4-hydroxy-L-proline[m] = 2 H+[m] + L-1-pyrroline-3-hydroxy-5-carboxylate[m] + NADH[m]
Left to rightBalancedEC 1.5.1.2Human-GEM MAR04779
NADP+[c] + trans-4-hydroxy-L-proline[c] = 2 H+[c] + L-1-pyrroline-3-hydroxy-5-carboxylate[c] + NADPH[c]
Left to rightBalancedEC 1.5.1.2Human-GEM MAR04780
NADP+[m] + trans-4-hydroxy-L-proline[m] = 2 H+[m] + L-1-pyrroline-3-hydroxy-5-carboxylate[m] + NADPH[m]
Left to rightBalancedEC 1.5.1.2Human-GEM MAR04781
2 H2O[m] + L-1-pyrroline-3-hydroxy-5-carboxylate[m] + NAD+[m] = H+[m] + L-erythro-4-hydroxyglutamate[m] + NADH[m]
Left to rightBalancedEC 1.2.1.88Human-GEM MAR04784
2 H2O[m] + L-1-pyrroline-3-hydroxy-5-carboxylate[m] + NADP+[m] = H+[m] + L-erythro-4-hydroxyglutamate[m] + NADPH[m]
Left to rightBalancedEC 1.2.1.88Human-GEM MAR04785
AKG[m] + L-erythro-4-hydroxyglutamate[m] = 4-hydroxy-2-oxoglutarate[m] + glutamate[m]
Left to rightBalancedEC 2.6.1.1, 2.6.1.23Human-GEM MAR04786
4-hydroxy-2-oxoglutarate[m] = glyoxalate[m] + pyruvate[m]
Left to rightBalancedEC 4.1.3.16Human-GEM MAR04787
5-methylthioadenosine[c] + Pi[c] = adenine[c] + methylthioribose-1p[c]
Left to rightBalancedEC 2.4.2.28Human-GEM MAR05384
CoA[c] + H+[c] + N1-acetylspermine[c] = acetyl-CoA[c] + spermine[c]
ReversibleBalancedEC 2.3.1.57Human-GEM MAR06929
CoA[x] + H+[x] + N1-acetylspermine[x] = acetyl-CoA[x] + spermine[x]
ReversibleBalancedEC 2.3.1.57Human-GEM MAR06930
H2O[c] + O2[c] + spermine[c] = H+[c] + H2O2[c] + NH3[c] + spermine monoaldehyde[c]
Left to rightBalancedEC 1.4.3.21, 1.4.3.22Human-GEM MAR06931
H2O[e] + O2[e] + spermine[e] = H+[e] + H2O2[e] + NH3[e] + spermine monoaldehyde[e]
Left to rightBalancedEC 1.4.3.21, 1.4.3.22Human-GEM MAR06932
FAD[x] + H2O[x] + spermine[x] = FADH2[x] + H+[x] + NH3[x] + spermine monoaldehyde[x]
Left to rightBalancedEC 1.4.3.21, 1.4.3.22Human-GEM MAR06933
H2O[c] + O2[c] + spermine monoaldehyde[c] = H+[c] + H2O2[c] + NH3[c] + spermine dialdehyde[c]
Left to rightBalancedEC 1.4.3.21, 1.4.3.22Human-GEM MAR06934
H2O[e] + O2[e] + spermine monoaldehyde[e] = H+[e] + H2O2[e] + NH3[e] + spermine dialdehyde[e]
Left to rightBalancedEC 1.4.3.21, 1.4.3.22Human-GEM MAR06935
FAD[x] + H2O[x] + spermine monoaldehyde[x] = FADH2[x] + H+[x] + NH3[x] + spermine dialdehyde[x]
Left to rightBalancedEC 1.4.3.21, 1.4.3.22Human-GEM MAR06936
CoA[c] + H+[c] + N1-acetylspermidine[c] = acetyl-CoA[c] + spermidine[c]
ReversibleBalancedEC 2.3.1.57Human-GEM MAR06938