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Subsystem: Androgen metabolism Remove
36 reactions in Androgen metabolism
H+[c] + NADPH[c] + O2[c] + pregnenolone[c] = 17alpha-hydroxypregnenolone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.19Human-GEM MAR01944
H+[r] + NADPH[r] + O2[r] + pregnenolone[r] = 17alpha-hydroxypregnenolone[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.19Human-GEM MAR01945
PAPS[c] + pregnenolone[c] = H+[c] + PAP[c] + pregnenolone sulfate[c]
Left to rightBalancedEC 2.8.2.2Human-GEM MAR01952
H2O[c] + pregnenolone sulfate[c] = H+[c] + pregnenolone[c] + sulfate[c]
Left to rightBalancedEC 3.1.6.2Human-GEM MAR01953
17alpha-hydroxypregnenolone[c] + 2 H+[c] + 2 NADPH[c] + O2[c] = acetaldehyde[c] + dehydroepiandrosterone[c] + 2 H2O[c] + 2 NADP+[c]
Left to right
17alpha-hydroxypregnenolone[c] + NADPH[c] + O2[c] = acetate[c] + dehydroepiandrosterone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.99.-Human-GEM MAR01959
17alpha-hydroxypregnenolone[r] + NADPH[r] + O2[r] = acetate[r] + dehydroepiandrosterone[r] + H2O[r] + NADP+[r]
ReversibleBalancedEC 1.14.99.-Human-GEM MAR01960
17alpha-hydroxypregnenolone[c] + PAPS[c] = 17alpha-hydroxypregnenolone sulfate[c] + H+[c] + PAP[c]
Left to rightBalancedEC 2.8.2.2Human-GEM MAR01962
17alpha-hydroxypregnenolone sulfate[c] + H2O[c] = 17alpha-hydroxypregnenolone[c] + H+[c] + sulfate[c]
Left to rightBalancedEC 3.1.6.2Human-GEM MAR01963
dehydroepiandrosterone[c] + NAD+[c] = 5-androstene-3,17-dione[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.145Human-GEM MAR01967
dehydroepiandrosterone[r] + NAD+[r] = 5-androstene-3,17-dione[r] + H+[r] + NADH[r]
Left to rightBalancedEC 1.1.1.145Human-GEM MAR01968
dehydroepiandrosterone[c] + PAPS[c] = dehydroepiandrosterone sulfate[c] + H+[c] + PAP[c]
Left to rightBalancedEC 2.8.2.4Human-GEM MAR01969
5-androstene-3,17-dione[c] + H+[c] + NAD+[c] = 4-androstene-3,17-dione[c] + NADH[c]
Left to rightUnbalancedEC 5.3.3.1Human-GEM MAR01970
5-androstene-3,17-dione[r] + H+[r] + NAD+[r] = 4-androstene-3,17-dione[r] + NADH[r]
Left to rightUnbalancedEC 5.3.3.1Human-GEM MAR01971
4-androstene-3,17-dione[c] + H+[c] + NADPH[c] = NADP+[c] + testosterone[c]
Left to rightBalancedEC 1.1.1.62, 1.1.1.64Human-GEM MAR01973
4-androstene-3,17-dione[r] + H+[r] + NADPH[r] = NADP+[r] + testosterone[r]
Left to rightBalancedEC 1.1.1.62, 1.1.1.64Human-GEM MAR01974
H+[c] + NADPH[c] + testosterone[c] = 5-alpha-dihydrotestosterone[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.22Human-GEM MAR01976
H+[r] + NADPH[r] + testosterone[r] = 5-alpha-dihydrotestosterone[r] + NADP+[r]
Left to rightBalancedEC 1.3.1.22Human-GEM MAR01977
5-alpha-dihydrotestosterone[c] + H+[c] + NADPH[c] = 5alpha-androstane-3alpha,17beta-diol[c] + NADP+[c]
ReversibleBalancedEC 1.1.1.50Human-GEM MAR01978
17alpha-hydroxypregnenolone[c] + NAD+[c] = H+[c] + NADH[c] + pregn-5-ene-3,20-dione-17-ol[c]
Left to rightBalancedEC 1.1.1.145Human-GEM MAR01982
pregn-5-ene-3,20-dione-17-ol[c] = 17alpha-hydroxyprogesterone[c]
Left to rightBalancedEC 5.3.3.1Human-GEM MAR01983
4-androstene-3,17-dione[c] + H+[c] + NADPH[c] = 5alpha-androstane-3,17-dione[c] + NADP+[c]
ReversibleBalancedEC 1.3.1.3, 1.3.99.6Human-GEM MAR02014
4-androstene-3,17-dione[r] + H+[r] + NADPH[r] = 5alpha-androstane-3,17-dione[r] + NADP+[r]
ReversibleBalancedEC 1.3.1.22Human-GEM MAR02015
5alpha-androstane-3,17-dione[c] + H+[c] + NADH[c] = androsterone[c] + NAD+[c]
Left to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50Human-GEM MAR02016
5alpha-androstane-3,17-dione[r] + H+[r] + NADH[r] = androsterone[r] + NAD+[r]
Left to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50Human-GEM MAR02017
5alpha-androstane-3,17-dione[c] + H+[c] + NADPH[c] = androsterone[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50Human-GEM MAR02018
5alpha-androstane-3,17-dione[r] + H+[r] + NADPH[r] = androsterone[r] + NADP+[r]
Left to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50Human-GEM MAR02019
androsterone sulfate[c] + H2O[c] = androsterone[c] + H+[c] + sulfate[c]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02020
5-alpha-dihydrotestosterone[c] + NADH[c] = androstenediol[c] + H+[c] + NAD+[c]
ReversibleUnbalancedEC 1.1.1.145Human-GEM MAR02022
5-alpha-dihydrotestosterone[r] + NADH[r] = androstenediol[r] + H+[r] + NAD+[r]
ReversibleUnbalancedEC 1.1.1.145Human-GEM MAR02024
5-alpha-dihydrotestosterone[c] + H+[c] + sulfate[c] = 5alpha-dihydrotestosterone-sulfate[c] + H2O[c]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02025
androstenediol[m] + H+[m] + NAD+[m] = 5-alpha-dihydrotestosterone[m] + NADH[m]
ReversibleUnbalancedEC 1.1.1.145Human-GEM MAR03400
5-alpha-dihydrotestosterone[l] + H+[l] + sulfate[l] = 5alpha-dihydrotestosterone-sulfate[l] + H2O[l]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR03600
5-alpha-dihydrotestosterone[r] + H+[r] + sulfate[r] = 5alpha-dihydrotestosterone-sulfate[r] + H2O[r]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR03601
androsterone[l] + H+[l] + sulfate[l] = androsterone sulfate[l] + H2O[l]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR03602
androsterone[r] + H+[r] + sulfate[r] = androsterone sulfate[r] + H2O[r]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR03603