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Subsystem: Tryptophan metabolism Remove
17 reactions in Tryptophan metabolism
5-hydroxyindoleacetaldehyde[m] + H2O[m] + NAD+[m] = 5-hydroxyindoleacetate[m] + 2 H+[m] + NADH[m]
Left to rightBalancedEC 1.2.1.88Human-GEM MAR00051
AKG[m] + kynurenine[m] = 4-hydroxy-2-quinolinecarboxylic acid[m] + glutamate[m] + H2O[m]
Left to rightBalancedEC 2.6.1.7Human-GEM MAR02765
5-hydroxytryptophol[m] + NADP+[m] = 5-hydroxyindoleacetaldehyde[m] + H+[m] + NADPH[m]
ReversibleBalancedEC 1.1.1.1Human-GEM MAR02858
3-hydroxy-L-kynurenine[m] + AKG[m] = glutamate[m] + H2O[m] + xanthurenate[m]
ReversibleBalancedEC 2.6.1.7Human-GEM MAR03048
H2O[c] + melatonin[c] = 6-hydroxymelatonin[c] + 2 H+[c]
ReversibleUnbalancedEC 3.4.21.59
4 H+[c] + 3 melatonin[c] + 4 O2-[c] = 3 formyl-N-acetyl-5-methoxykynurenamine[c] + 2 H2O[c]
Left to rightBalancedEC 2.5.1.18Human-GEM MAR03120
3-hydroxykynurenine-O-beta-D-glucoside[m] + GSH[m] = glutathionyl-3-hydroxykynurenine glucoside[m] + H2O[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR03124
crotonyl-CoA[m] + H2O[m] = (S)-3-hydroxybutyryl-CoA[m]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR03164
(S)-3-hydroxybutyryl-CoA[m] + NAD+[m] = acetoacetyl-CoA[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Human-GEM MAR03166
H2O[c] + melatonin[c] = H+[c] + melatonin radical[c]
ReversibleUnbalancedEC 3.4.15.1Human-GEM MAR03168
melatonin radical[c] = cyclic-3-hydroxymelatonin[c] + H+[c]
Left to rightUnbalancedHuman-GEM MAR03255
acetoacetyl-CoA[m] + CoA[m] = 2 acetyl-CoA[m]
ReversibleBalancedEC 2.3.1.9Human-GEM MAR03885
2-amino-3-carboxymuconate semialdehyde[c] = H+[c] + H2O[c] + quinolinate[c]
Left to rightBalancedHuman-GEM MAR04250
3-hydroxy-L-kynurenine[c] + H+[c] = 3-hydroxykynurenamine[c] + CO2[c]
Left to rightBalancedEC 4.1.1.28Human-GEM MAR08091
3-hydroxykynurenamine[c] + O2[c] = 4,8-dihydroxyquinoline[c] + H+[c] + H2O2[c] + NH3[c]
Left to rightBalancedEC 1.4.3.4Human-GEM MAR08092
H2O[m] + indole-3-acetaldehyde[m] + NAD+[m] = 2 H+[m] + indoleacetate[m] + NADH[m]
Left to rightBalancedEC 1.2.1.4, 1.2.1.5Human-GEM MAR08563
H+[c] + melatonin[c] + NADPH[c] + O2[c] = 6-hydroxymelatonin[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.1Human-GEM MAR08566