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Subsystem: Steroid metabolism Remove
1–50 of 92 reactions in Steroid metabolism
bilirubin[r] + UDP-glucuronate[r] = bilirubin-monoglucuronoside[r] + UDP[r]
ReversibleBalancedEC 2.4.1.17Human-GEM MAR01820
cholesterol-sulfate[c] + H2O[c] = cholesterol[c] + H+[c] + sulfate[c]
Left to rightBalancedEC 3.1.6.2Human-GEM MAR01920
cholesterol[c] + STAR[c] = cholesterol-STAR[c]
Left to rightBalancedHuman-GEM MAR01924
cholesterol-STAR[m] = cholesterol[m] + STAR[m]
Left to rightBalancedHuman-GEM MAR01926
cholesterol[m] + H+[m] + NADPH[m] + O2[m] = 22beta-hydroxycholesterol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR01927
22beta-hydroxycholesterol[m] + H+[m] + NADPH[m] + O2[m] = 20alpha,22beta dihydroxycholesterol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.16Human-GEM MAR01928
20alpha,22beta dihydroxycholesterol[m] + H+[m] + NADPH[m] + O2[m] = 2 H2O[m] + isocaproic-aldehyde[m] + NADP+[m] + pregnenolone[m]
Left to rightBalancedEC 1.14.15.16Human-GEM MAR01929
H+[c] + isocaproic-aldehyde[c] + NADPH[c] = 4-methylpentan-1-ol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.21Human-GEM MAR01931
cholesterol[c] + 2 H+[c] + O2[c] + 2 reduced adrenal ferredoxin[c] = 20-hydroxycholesterol[c] + H2O[c] + 2 oxidized adrenal ferredoxin[c]
Left to rightBalance undeterminableEC 1.14.15.6Human-GEM MAR01932
20-hydroxycholesterol[c] + H+[c] + NADPH[c] + O2[c] = 17alpha,20alpha-dihydroxycholesterol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.19Human-GEM MAR01933
17alpha,20alpha-dihydroxycholesterol[c] + 4 H+[c] + 2 O2[c] + 4 reduced adrenal ferredoxin[c] = 17alpha-hydroxypregnenolone[c] + 3 H2O[c] + isocaproic-aldehyde[c] + 4 oxidized adrenal ferredoxin[c]
Left to rightBalance undeterminableEC 1.14.15.6Human-GEM MAR01934
20-hydroxycholesterol[c] + 2 H+[c] + O2[c] + 2 reduced adrenal ferredoxin[c] = 20alpha,22beta dihydroxycholesterol[c] + H2O[c] + 2 oxidized adrenal ferredoxin[c]
Left to rightBalance undeterminableEC 1.14.15.6Human-GEM MAR01935
H+[c] + NADPH[c] + O2[c] + pregnenolone[c] = 21-hydroxypregnenolone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.16Human-GEM MAR01940
21-hydroxypregnenolone[c] + NAD+[c] = 11-deoxycorticosterone[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.145, 5.3.3.1Human-GEM MAR01941
11-deoxycorticosterone[c] + 2 H+[c] + O2[c] + 2 reduced ferredoxin[c] = corticosterone[c] + H2O[c] + 2 oxidized ferredoxin[c]
Left to rightBalance undeterminableEC 1.14.15.4Human-GEM MAR01942
H+[c] + NADPH[c] + O2[c] + pregnenolone[c] = 7alpha-hydroxypregnenolone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.29Human-GEM MAR01943
17alpha-hydroxypregnenolone[c] + H+[c] + NADPH[c] + O2[c] = 17alpha,21-dihydroxypregnenolone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.16Human-GEM MAR01948
17alpha,21-dihydroxypregnenolone[c] + NAD+[c] = 11-deoxycortisol[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.145, 5.3.3.1Human-GEM MAR01949
17alpha,21-dihydroxypregnenolone[c] + 2 H+[c] + O2[c] + 2 reduced ferredoxin[c] = 11beta,17alpha,21-trihydroxypregnenolone[c] + H2O[c] + 2 oxidized ferredoxin[c]
Left to rightBalance undeterminableEC 1.14.15.4Human-GEM MAR01950
11beta,17alpha,21-trihydroxypregnenolone[c] + NAD+[c] = cortisol[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.145, 5.3.3.1Human-GEM MAR01951
17alpha-hydroxyprogesterone[c] + H+[c] + NADPH[c] + O2[c] = 21-deoxycortisol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.15.4Human-GEM MAR01989
cortisol[c] + H2O[c] + NADP+[c] = 21-deoxycortisol[c] + H+[c] + NADPH[c] + O2[c]
Left to rightBalancedEC 1.14.14.16Human-GEM MAR01990
21-deoxycortisol[c] + H2O[c] + NADP+[c] = 11beta-hydroxyprogesterone[c] + H+[c] + NADPH[c] + O2[c]
Left to rightBalancedEC 1.14.14.19Human-GEM MAR01991
11beta-hydroxyprogesterone[c] + H+[c] + NADPH[c] + O2[c] = corticosterone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.16Human-GEM MAR01992
H+[c] + NADPH[c] + O2[c] + progesterone[c] = 11beta-hydroxyprogesterone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.15.4Human-GEM MAR01993
5alpha-pregnane-3,20-dione[c] + NADP+[c] = H+[c] + NADPH[c] + progesterone[c]
ReversibleBalancedEC 1.3.1.22Human-GEM MAR02002
allopregnanolone[c] + NADP+[c] = 5alpha-pregnane-3,20-dione[c] + H+[c] + NADPH[c]
ReversibleBalancedEC 1.1.1.213Human-GEM MAR02003
5alpha-pregnane-3,20-dione[c] + H+[c] + NADH[c] = allopregnanolone[c] + NAD+[c]
ReversibleBalancedEC 1.1.1.50Human-GEM MAR02004
allopregnanolone[c] + H+[c] + NADH[c] + O2[c] = 21-hydroxyallopregnanolone[c] + H2O[c] + NAD+[c]
Left to rightBalancedEC 1.14.14.16Human-GEM MAR02005
H+[c] + NADPH[c] + O2[c] + progesterone[c] = 11-deoxycorticosterone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.16Human-GEM MAR02007
11-deoxycorticosterone[m] + H+[m] + NADPH[m] + O2[m] = corticosterone[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.4Human-GEM MAR02009
corticosterone[m] + H+[m] + NADPH[m] + O2[m] = 18-hydroxycorticosterone[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.5Human-GEM MAR02010
18-hydroxycorticosterone[m] + H+[m] + NADPH[m] + O2[m] = aldosterone[m] + 2 H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.5Human-GEM MAR02011
estrone[r] + H+[r] + NADPH[r] = estradiol-17beta[r] + NADP+[r]
ReversibleBalancedEC 1.1.1.62Human-GEM MAR02041
17alpha-hydroxyprogesterone[m] + NADPH[m] + O2[m] = 4-androstene-3,17-dione[m] + acetate[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR02723
17alpha-hydroxypregnenolone sulfate[g] + H2O[g] = 17alpha-hydroxypregnenolone[g] + H+[g] + sulfate[g]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02725
17alpha-hydroxypregnenolone sulfate[l] + H2O[l] = 17alpha-hydroxypregnenolone[l] + H+[l] + sulfate[l]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02728
17alpha-hydroxypregnenolone sulfate[r] + H2O[r] = 17alpha-hydroxypregnenolone[r] + H+[r] + sulfate[r]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02743
cholesterol-sulfate[g] + H2O[g] = cholesterol[g] + H+[g] + sulfate[g]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02747
cholesterol-sulfate[l] + H2O[l] = cholesterol[l] + H+[l] + sulfate[l]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02749
17alpha-hydroxypregnenolone[m] + NADPH[m] + O2[m] = acetate[m] + dehydroepiandrosterone[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR02751
H2O[g] + pregnenolone sulfate[g] = H+[g] + pregnenolone[g] + sulfate[g]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02756
H2O[l] + pregnenolone sulfate[l] = H+[l] + pregnenolone[l] + sulfate[l]
ReversibleBalancedEC 3.1.6.2Human-GEM MAR02763
cortisol[r] + H+[r] + NADPH[r] = 11beta-hydroxyandrost-4-ene-3,17-dione[r] + acetaldehyde[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR03257
bilirubin[r] + 2 UDP-glucuronate[r] = bilirubin-bisglucuronoside[r] + 2 UDP[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR04766
iodine[c] + tyrosine[c] = 3-iodo-L-tyrosine[c] + H+[c] + hydroiodic acid[c]
Left to rightBalancedEC 1.11.1.8Human-GEM MAR06793
3-iodo-L-tyrosine[c] + iodine[c] = 3,5-diiodo-L-tyrosine[c] + H+[c] + hydroiodic acid[c]
Left to rightBalancedEC 1.11.1.8Human-GEM MAR06794
2 3,5-diiodo-L-tyrosine[c] + H2O2[c] = dehydroalanine[c] + 2 H2O[c] + thyroxine[c]
Left to rightBalancedEC 1.11.1.8Human-GEM MAR06795
3,5-diiodo-L-tyrosine[c] + 3-iodo-L-tyrosine[c] + H2O2[c] = dehydroalanine[c] + 2 H2O[c] + triiodothyronine[c]
Left to rightBalancedEC 1.11.1.8Human-GEM MAR06796
estradiol-17beta[r] + UDP-glucuronate[r] = estradiol-17beta 3-glucuronide[r] + UDP[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR07648