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Subsystem: Prostaglandin biosynthesis Remove
1–50 of 71 reactions in Prostaglandin biosynthesis
arachidonate[r] + 2 O2[r] = prostaglandin G2[r]
Left to rightBalancedEC 1.14.99.1Human-GEM MAR01305
2 H+[r] + prostaglandin G2[r] = H2O[r] + prostaglandin H2[r]
Left to rightUnbalancedEC 1.14.99.1Human-GEM MAR01307
prostaglandin H2[r] = prostaglandin I2[r]
Left to rightBalancedEC 5.3.99.4Human-GEM MAR01308
6-oxo-prostaglandin F1alpha[r] = H2O[r] + prostaglandin I2[r]
ReversibleBalancedHuman-GEM MAR01310
prostaglandin H2[c] = prostaglandin E2[c]
Left to rightBalancedEC 5.3.99.3Human-GEM MAR01312
prostaglandin H2[r] = thromboxane A2[r]
Left to rightBalancedEC 5.3.99.5Human-GEM MAR01313
H2O[r] + thromboxane A2[r] = thromboxane B2[r]
ReversibleBalancedHuman-GEM MAR01315
11-dehydro-thromboxane B2[c] + H+[c] + NADH[c] = NAD+[c] + thromboxane B2[c]
ReversibleBalancedHuman-GEM MAR01317
6-oxo-prostaglandin F1alpha[c] = H2O[c] + prostaglandin I2[c]
ReversibleBalancedHuman-GEM MAR01318
6-oxo-prostaglandin E1[c] + H+[c] + NADH[c] = 6-oxo-prostaglandin F1alpha[c] + NAD+[c]
ReversibleBalancedHuman-GEM MAR01319
6-oxo-prostaglandin F1alpha[c] + 2 H+[c] + 2 NADH[c] = H2O[c] + 2 NAD+[c] + prostaglandin F1alpha[c]
ReversibleBalancedHuman-GEM MAR01320
H2O[c] + prostaglandin A2[c] = prostaglandin E2[c]
ReversibleBalancedEC 4.2.1.-Human-GEM MAR01321
prostaglandin A2[c] = prostaglandin C2[c]
ReversibleBalancedEC 5.3.-.-Human-GEM MAR01322
prostaglandin B2[c] = prostaglandin C2[c]
ReversibleBalancedEC 5.3.3.9Human-GEM MAR01323
H2O[c] + prostaglandin B2[c] = prostaglandin E2[c]
ReversibleBalancedHuman-GEM MAR01324
NAD+[c] + prostaglandin F2alpha[c] = H+[c] + NADH[c] + prostaglandin H2[c]
Left to rightBalancedEC 1.1.1.188Human-GEM MAR01325
NADP+[c] + prostaglandin F2alpha[c] = H+[c] + NADPH[c] + prostaglandin H2[c]
Left to rightBalancedEC 1.1.1.188Human-GEM MAR01326
NADP+[c] + prostaglandin F2alpha[c] = H+[c] + NADPH[c] + prostaglandin E2[c]
Left to rightBalancedEC 1.1.1.184, 1.1.1.189Human-GEM MAR01327
15-keto-prostaglandin F2alpha[c] + H+[c] + NADH[c] = NAD+[c] + prostaglandin F2alpha[c]
ReversibleBalancedHuman-GEM MAR01328
H+[c] + NADPH[c] + prostaglandin D2[c] = NADP+[c] + prostaglandin F2alpha[c]
ReversibleBalancedEC 1.1.1.188Human-GEM MAR01329
prostaglandin H2[c] = prostaglandin D2[c]
Left to rightBalancedEC 5.3.99.2Human-GEM MAR01330
H2O[c] + prostaglandin J2[c] = prostaglandin D2[c]
ReversibleBalancedHuman-GEM MAR01332
H2O[r] + prostaglandin J2[r] = prostaglandin D2[r]
ReversibleBalancedHuman-GEM MAR01333
15-deoxy-PGD2[c] + H2O[c] = prostaglandin D2[c]
ReversibleBalancedHuman-GEM MAR01334
delta-12-prostaglandin J2[r] + H2O[r] = prostaglandin D2[r]
ReversibleBalancedHuman-GEM MAR01335
15-dehydro-prostaglandin D2[c] + H+[c] + NADPH[c] = NADP+[c] + prostaglandin D2[c]
ReversibleBalancedHuman-GEM MAR01336
13,14-dihydro-15-keto-PGD2[c] = 15-dehydro-prostaglandin D2[c] + 2 H+[c]
ReversibleUnbalancedHuman-GEM MAR01337
15-deoxy-delta-12,14-PGD2[c] + H2O[c] = prostaglandin D2[c]
ReversibleBalancedHuman-GEM MAR01338
12(S)-HHT[c] + H+[c] + malonic-dialdehyde[c] = prostaglandin H2[c]
ReversibleBalancedEC 5.3.99.5Human-GEM MAR01339
H2O[c] + prostaglandin-PGE2-glyceryl ester[c] = glycerol[c] + H+[c] + prostaglandin E2[c]
ReversibleBalancedEC 3.1.-.-Human-GEM MAR01341
H2O[c] + prostaglandin-PGE2-1-glyceryl ester[c] = glycerol[c] + H+[c] + prostaglandin E2[c]
ReversibleBalancedEC 3.1.-.-Human-GEM MAR01342
H2O[c] + prostaglandin-PGE2-3-glyceryl ester[c] = glycerol[c] + H+[c] + prostaglandin E2[c]
ReversibleBalancedEC 3.1.-.-Human-GEM MAR01343
15-oxo-prostaglandin E2-glyceryl ester[c] + H+[c] + NADPH[c] = NADP+[c] + prostaglandin-PGE2-glyceryl ester[c]
ReversibleBalancedEC 1.1.1.141Human-GEM MAR01344
H2O[c] + prostaglandin-PGB2-glyceryl ester[c] = prostaglandin-PGE2-glyceryl ester[c]
ReversibleBalancedHuman-GEM MAR01345
arachidonate[c] + ethanolamine[c] = anandamide[c] + H2O[c]
Left to rightBalancedEC 3.5.1.99Human-GEM MAR01346
2-arachidonoylglycerol[c] + H2O[c] = arachidonate[c] + glycerol[c] + H+[c]
ReversibleBalancedEC 3.5.1.99Human-GEM MAR01347
2-arachidonoylglycerol[c] + O2[c] = 12-hydroperoxyeicosatetraenoate-glyceryl-ester[c]
Left to rightBalancedEC 1.14.99.1Human-GEM MAR01350
1-lyso-2-arachidonoyl-phosphatidate[c] + H2O[c] = 2-arachidonoylglycerol[c] + Pi[c]
ReversibleBalancedEC 3.1.3.4Human-GEM MAR01352
arachidonate[c] + O2[c] = 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate[c] + H+[c]
Left to rightUnbalancedHuman-GEM MAR01355
8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate[c] + ascorbate[c] + O2[c] = 5,9-cyclo-6,8-cycloperoxy-12-hydroperoxy-(10E,14Z)-eicosadienoate[c] + monodehydroascorbate[c]
Left to rightBalancedHuman-GEM MAR01356
5,9-cyclo-6,8-cycloperoxy-12-hydroperoxy-(10E,14Z)-eicosadienoate[c] + 2 ascorbate[c] = 5,9-cyclo-6,8,12-trihydroxy-(10E,14Z)-eicosadienoic acid[c] + 2 dehydroascorbic acid[c] + H2O[c]
Left to rightBalancedHuman-GEM MAR01357
arachidonate[c] + O2-[c] = 9-peroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate[c] + H+[c]
Left to rightUnbalancedHuman-GEM MAR01358
9-peroxy-(5Z,7E,11Z,14Z)-eicosatetraenoate[c] + ascorbate[c] + O2[c] = 9,11-cycloperoxy-5-hydroperoxy-(6E,14Z)-eicosadienoate[c] + monodehydroascorbate[c]
Left to rightBalancedHuman-GEM MAR01359
9,11-cycloperoxy-5-hydroperoxy-(6E,14Z)-eicosadienoate[c] + 2 ascorbate[c] = 5,9,11-trihydroxyprosta-(6E,14Z)-dien-1-oate[c] + 2 dehydroascorbic acid[c] + H2O[c]
Left to rightBalancedHuman-GEM MAR01360
arachidonate[c] + O2-[c] = 11-peroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate[c] + H+[c]
Left to rightUnbalancedHuman-GEM MAR01361
11-peroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate[c] + ascorbate[c] + O2[c] = 9,11-cycloperoxy-15-hydroperoxy-(5Z,13E)-eicosadienoate[c] + monodehydroascorbate[c]
Left to rightBalancedHuman-GEM MAR01362
9,11,15-trihydroxyprosta-(5Z,13E)-dien-1-oate[c] + H2O[c] = 9,11-cycloperoxy-15-hydroperoxy-(5Z,13E)-eicosadienoate[c] + 4 H+[c]
ReversibleUnbalancedHuman-GEM MAR01363
arachidonate[c] + O2-[c] = 12-peroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate[c] + H+[c]
Left to rightUnbalancedHuman-GEM MAR01364
12-peroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate[c] + ascorbate[c] + O2[c] = 11,15-cyclo-12,14-cycloperoxy-8-hydroperoxy-(5Z,9E)-eicosadienoate[c] + monodehydroascorbate[c]
Left to rightBalancedHuman-GEM MAR01365
11,15-cyclo-12,14-cycloperoxy-8-hydroperoxy-(5Z,9E)-eicosadienoate[c] + 4 H+[c] = 11,15-cyclo-8,12,14-trihydroxy-(5Z,9E)-eicosadienoic acid[c] + H2O[c]
ReversibleUnbalancedHuman-GEM MAR01366