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Subsystem: Omega-6 fatty acid metabolism Remove
1–50 of 59 reactions in Omega-6 fatty acid metabolism
H+[c] + linoleoyl-CoA[c] + NADPH[c] + O2[c] = gamma-linolenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.3Human-GEM MAR02368
gamma-linolenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-dihomo-gamma-linolenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02371
3-oxo-dihomo-gamma-linolenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[c] + NADP+[c]
Left to rightBalancedHuman-GEM MAR02374
3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[c] = H2O[c] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[c]
Left to rightBalancedHuman-GEM MAR02376
H+[c] + NADPH[c] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[c] = dihomo-gamma-linolenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02378
dihomo-gamma-linolenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = arachidonyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.-Human-GEM MAR02380
arachidonyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02383
3-oxo-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02387
3(S)-hydroxy-docosa-7,10,13,16-all-cis-tetraenoyl-CoA[c] = (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[c] + H2O[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02389
(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[c] + H+[c] + NADPH[c] = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedHuman-GEM MAR02391
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedHuman-GEM MAR02393
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-tetracosa-9,12,15,18-all-cis-tetraenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02395
3-oxo-tetracosa-9,12,15,18-all-cis-tetraenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02397
3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] = 2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA[c] + H2O[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02399
2-trans-9,12,15,18-all-cis-tetracosapentaenoyl-CoA[c] + H+[c] + NADPH[c] = (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02401
(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedHuman-GEM MAR02403
(6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA[x] + FAD[x] = FADH2[x] + trans-2-all-cis-6,9,12,15,18-tetracosahexaenoyl-CoA[x]
Left to rightBalancedEC 1.3.3.6Human-GEM MAR02408
H2O[x] + trans-2-all-cis-6,9,12,15,18-tetracosahexaenoyl-CoA[x] = 3(S)-hydroxy-tetracosa-6,9,12,15,18-all-cis-pentaenoyl-CoA[x]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR02409
3(S)-hydroxy-tetracosa-6,9,12,15,18-all-cis-pentaenoyl-CoA[x] + NAD+[x] = 3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Human-GEM MAR02410
3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[x] + CoA[x] = (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA[x] + acetyl-CoA[x]
Left to rightBalancedEC 2.3.1.16Human-GEM MAR02411
dihomo-gamma-linolenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-docosa-cis,cis,cis-10,13,16-trienoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02415
3-oxo-docosa-cis,cis,cis-10,13,16-trienoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-10,13,16-all-cis-docosatrienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02417
3(S)-hydroxy-10,13,16-all-cis-docosatrienoyl-CoA[c] = H2O[c] + trans,cis,cis,cis-2,10,13,16-docosatetraenoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02419
H+[c] + NADPH[c] + trans,cis,cis,cis-2,10,13,16-docosatetraenoyl-CoA[c] = 10,13,16-docosatrienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02421
H+[c] + linoleoyl-CoA[c] + malonyl-CoA[c] = 3-oxoeicosa-cis,cis-11,14-dienoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02423
3-oxoeicosa-cis,cis-11,14-dienoyl-CoA[c] + H+[c] + NADPH[c] = (3S)-hydroxy-eicosa-cis,cis-11,14-dienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02426
(3S)-hydroxy-eicosa-cis,cis-11,14-dienoyl-CoA[c] = H2O[c] + trans,cis,cis-2,11,14-eicosatrienoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02428
H+[c] + NADPH[c] + trans,cis,cis-2,11,14-eicosatrienoyl-CoA[c] = (11Z,14Z)-eicosadienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02430
(11Z,14Z)-eicosadienoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxodocasa-cis,cis-13,16-dienoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02433
3-oxodocasa-cis,cis-13,16-dienoyl-CoA[c] + H+[c] + NADPH[c] = (3S)-hydroxy-docasa-cis,cis-13,16-dienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02434
(3S)-hydroxy-docasa-cis,cis-13,16-dienoyl-CoA[c] = H2O[c] + trans,cis,cis-2,13,16-docasatrienoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02435
H+[c] + NADPH[c] + trans,cis,cis-2,13,16-docasatrienoyl-CoA[c] = (13Z,16Z)-docosadienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02436
arachidonyl-CoA[m] + FAD[m] = 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[m] + FADH2[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Human-GEM MAR03444
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[m] = trans-3-cis-5,8,11,14-eicosapentaenoyl-CoA[m]
Left to rightBalancedEC 5.3.3.8Human-GEM MAR03445
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[m] + H+[m] + NADPH[m] = NADP+[m] + trans-3-cis-8,11,14-eicosatetraenoyl-CoA[m]
Left to rightBalancedEC 1.3.1.34Human-GEM MAR03446
trans-3-cis-8,11,14-eicosatetraenoyl-CoA[m] = trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[m]
Left to rightBalancedEC 5.3.3.8, 5.3.3.-Human-GEM MAR03447
dihomo-gamma-linolenoyl-CoA[m] + FAD[m] = FADH2[m] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Human-GEM MAR03448
H2O[m] + trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[m] = 3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[m]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR03449
3(S)-hydroxy-dihomo-gamma-linolenoyl-CoA[m] + NAD+[m] = 3-oxo-dihomo-gamma-linolenoyl-CoA[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Human-GEM MAR03450
FAD[m] + gamma-linolenoyl-CoA[m] = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA[m] + FADH2[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Human-GEM MAR03452
(2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA[m] + H2O[m] = 3(S)-hydroxy-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR03453
3(S)-hydroxy-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m] + NAD+[m] = 3-oxo-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m] + H+[m] + NADH[m]
ReversibleBalancedEC 1.1.1.35, 1.1.1.211Human-GEM MAR03454
(4Z,7Z,10Z)-hexadecatrienoyl-CoA[m] + acetyl-CoA[m] = 3-oxo-(6Z,9Z,12Z)-octadecatrienoyl-CoA[m] + CoA[m]
ReversibleBalancedEC 2.3.1.16, 1.1.1.211Human-GEM MAR03455
(4Z,7Z,10Z)-hexadecatrienoyl-CoA[m] + O2[m] = (2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA[m] + H2O2[m]
Left to rightBalancedEC 1.3.8.7, 1.3.8.8, 1.3.8.9, 1.3.99.-Human-GEM MAR03456
(2E,4Z,7Z,10Z)-hexadecatetraenoyl-CoA[m] + H+[m] + NADPH[m] = (3Z,7Z,10Z)-hexadecatrienoyl-CoA[m] + NADP+[m]
ReversibleBalancedEC 1.3.1.34Human-GEM MAR03457
(3Z,7Z,10Z)-hexadecatrienoyl-CoA[m] = trans,cis,cis-2,7,10-hexadecatrienoyl-CoA[m]
Left to rightBalancedEC 5.3.3.8Human-GEM MAR03458
arachidonyl-CoA[x] + FAD[x] = 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[x] + FADH2[x]
Left to rightBalancedEC 1.3.3.6Human-GEM MAR03459
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[x] = trans-3-cis-5,8,11,14-eicosapentaenoyl-CoA[x]
Left to rightBalancedEC 5.3.3.8Human-GEM MAR03460
2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA[x] + H+[x] + NADPH[x] = NADP+[x] + trans-3-cis-8,11,14-eicosatetraenoyl-CoA[x]
Left to rightBalancedEC 1.3.1.34Human-GEM MAR03461
trans-3-cis-8,11,14-eicosatetraenoyl-CoA[x] = trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA[x]
Left to rightBalancedEC 5.3.3.8Human-GEM MAR03462