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Subsystem: Omega-3 fatty acid metabolism Remove
1–50 of 74 reactions in Omega-3 fatty acid metabolism
H+[c] + linolenoyl-CoA[c] + NADPH[c] + O2[c] = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.-Human-GEM MAR02472
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-keto-eicosa-8,11,14,17-all-cis-tetraenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02475
3-keto-eicosa-8,11,14,17-all-cis-tetraenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-all-cis-8,11,14,17-eicosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02478
3(S)-hydroxy-all-cis-8,11,14,17-eicosatetraenoyl-CoA[c] = eicosa-(2E,8Z,11Z,14Z,17Z)-pentaenoyl-CoA[c] + H2O[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02480
eicosa-(2E,8Z,11Z,14Z,17Z)-pentaenoyl-CoA[c] + H+[c] + NADPH[c] = (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02482
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.-Human-GEM MAR02484
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-docosa-7,10,13,16,19-all-cis-pentaenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02486
3-oxo-docosa-7,10,13,16,19-all-cis-pentaenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-docosa-7,10,13,16,19-all-cis-pentaenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02489
3(S)-hydroxy-docosa-7,10,13,16,19-all-cis-pentaenoyl-CoA[c] = 2-trans-7,10,13,16,19-all-cis-docosahexaenoyl-CoA[c] + H2O[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02491
2-trans-7,10,13,16,19-all-cis-docosahexaenoyl-CoA[c] + H+[c] + NADPH[c] = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02493
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA[c] + H+[c] + NADPH[c] + O2[c] = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedHuman-GEM MAR02495
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02497
3-oxo-all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-tetracosa-9,12,15,18,21-all-cis-pentaenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02499
3(S)-hydroxy-tetracosa-9,12,15,18,21-all-cis-pentaenoyl-CoA[c] = 2-trans-9,12,15,18,21-all-cis-tetracosahexaenoyl-CoA[c] + H2O[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02501
2-trans-9,12,15,18,21-all-cis-tetracosahexaenoyl-CoA[c] + H+[c] + NADPH[c] = (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02503
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA[c] + H+[c] + NADH[c] + O2[c] = (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA[c] + 2 H2O[c] + NAD+[c]
Left to rightBalancedEC 1.14.19.3Human-GEM MAR02505
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA[x] + FAD[x] = delta2-THA-CoA[x] + FADH2[x]
Left to rightBalancedEC 1.3.3.6Human-GEM MAR02510
delta2-THA-CoA[x] + H2O[x] = 3-hydroxy-THA-CoA[x]
Left to rightBalancedEC 4.2.1.17Human-GEM MAR02511
3-hydroxy-THA-CoA[x] + NAD+[x] = 3-keto-THA-CoA[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Human-GEM MAR02512
3-keto-THA-CoA[x] + CoA[x] = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA[x] + acetyl-CoA[x]
Left to rightBalancedEC 2.3.1.16Human-GEM MAR02513
(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-docosa-10,13,16,19-all-cis-tetraenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02515
3-oxo-docosa-10,13,16,19-all-cis-tetraenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-docosa-10,13,16,19-all-cis-tetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02516
3(S)-hydroxy-docosa-10,13,16,19-all-cis-tetraenoyl-CoA[c] = H2O[c] + trans,cis,cis,cis,cis-2,10,13,16,19-docosapentaenoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02518
H+[c] + NADPH[c] + trans,cis,cis,cis,cis-2,10,13,16,19-docosapentaenoyl-CoA[c] = 10,13,16,19-docosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02520
10,13,16,19-docosatetraenoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02522
3-oxo-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02524
3(S)-hydroxy-tetracosa-12,15,18,21-all-cis-tetraenoyl-CoA[c] = H2O[c] + trans,cis,cis,cis,cis-2,12,15,18,21-tetracosapentaenoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02526
H+[c] + NADPH[c] + trans,cis,cis,cis,cis-2,12,15,18,21-tetracosapentaenoyl-CoA[c] = 12,15,18,21-tetracosatetraenoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02528
H+[c] + linolenoyl-CoA[c] + malonyl-CoA[c] = 3-oxoeicosa-cis,cis,cis-11,14,17-trienoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02530
3-oxoeicosa-cis,cis,cis-11,14,17-trienoyl-CoA[c] + H+[c] + NADPH[c] = (3S)-hydroxy-eicosa-cis,cis,cis-11,14,17-trienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02533
(3S)-hydroxy-eicosa-cis,cis,cis-11,14,17-trienoyl-CoA[c] = H2O[c] + trans,cis,cis,cis-2,11,14,17-eicosatetraenoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02535
H+[c] + NADPH[c] + trans,cis,cis,cis-2,11,14,17-eicosatetraenoyl-CoA[c] = (11Z,14Z,17Z)-eicosatrienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02537
(11Z,14Z,17Z)-eicosatrienoyl-CoA[c] + H+[c] + malonyl-CoA[c] = 3-oxo-docosa-13,16,19-all-cis-trienoyl-CoA[c] + CO2[c] + CoA[c]
Left to rightBalancedEC 2.3.1.199Human-GEM MAR02540
3-oxo-docosa-13,16,19-all-cis-trienoyl-CoA[c] + H+[c] + NADPH[c] = 3(S)-hydroxy-docosa-13,16,19-all-cis-trienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.330Human-GEM MAR02541
3(S)-hydroxy-docosa-13,16,19-all-cis-trienoyl-CoA[c] = H2O[c] + trans,cis,cis,cis-2,13,16,19-docosatetraenoyl-CoA[c]
Left to rightBalancedEC 4.2.1.134Human-GEM MAR02542
H+[c] + NADPH[c] + trans,cis,cis,cis-2,13,16,19-docosatetraenoyl-CoA[c] = 13,16,19-docosatrienoyl-CoA[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.93Human-GEM MAR02543
EPA[c] + O2[c] = 5(S)-HpEPE[c]
Left to rightBalancedEC 1.13.11.34Human-GEM MAR02544
5(S)-HEPE[c] + H2O[c] = 5(S)-HpEPE[c] + 2 H+[c]
ReversibleUnbalancedHuman-GEM MAR02545
5(S)-HEPE[c] + NADP+[c] = 5-oxo-EPE[c] + H+[c] + NADPH[c]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR02546
5(S)-HEPE[x] + NADP+[x] = 5-oxo-EPE[x] + H+[x] + NADPH[x]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR02548
5(S)-HpEPE[c] = H2O[c] + leukotriene A5[c]
ReversibleBalancedHuman-GEM MAR02549
H2O[c] + leukotriene A5[c] = 5,12-dihydroxy-(6E)-LTB5[c]
Left to rightBalancedHuman-GEM MAR02550
H2O[c] + leukotriene A5[c] = leukotriene B5[c]
ReversibleBalancedEC 3.3.2.6Human-GEM MAR02551
GSH[c] + leukotriene A5[c] = leukotriene C5[c]
ReversibleBalancedEC 4.4.1.20Human-GEM MAR02552
H+[c] + leukotriene B5[c] + NADPH[c] + O2[c] = 20-hydroxy-LTB5[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR02553
H+[r] + leukotriene B5[r] + NADPH[r] + O2[r] = 20-hydroxy-LTB5[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR02555
H2O[c] + leukotriene C5[c] = glutamate[c] + leukotriene D5[c]
ReversibleBalancedEC 2.3.2.2Human-GEM MAR02556
EPA[c] + O2[c] = 15(R)-HpEPE[c]
Left to rightBalancedEC 1.14.99.1Human-GEM MAR02557
15(R)-HpEPE[c] = 15(S)-HpEPE[c]
Left to rightBalancedHuman-GEM MAR02558
15(S)-HEPE[c] + H2O[c] = 15(S)-HpEPE[c] + 2 H+[c]
ReversibleUnbalancedHuman-GEM MAR02559