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Subsystem: Leukotriene metabolism Remove
1–50 of 170 reactions in Leukotriene metabolism
H2O[c] + leukotriene A4[c] = leukotriene B4[c]
Left to rightBalancedEC 3.3.2.6, 3.4.11.6Human-GEM MAR01080
GSH[c] + leukotriene A4[c] = leukotriene C4[c]
Left to rightBalancedEC 4.4.1.20Human-GEM MAR01081
H+[e] + leukotriene C4[e] = 5-L-gamma-glutamyl[e] + LTD4[e]
Left to rightBalancedEC 2.3.2.2Human-GEM MAR01084
H2O[e] + LTD4[e] = glycine[e] + leukotriene E4[e]
Left to rightBalancedEC 3.4.13.19Human-GEM MAR01085
H+[c] + leukotriene E4[c] = 11-trans-LTE4[c]
Left to rightBalancedHuman-GEM MAR01087
CoA[c] + H+[c] + N-acetyl-LTE4[c] = acetyl-CoA[c] + leukotriene E4[c]
ReversibleBalancedEC 2.3.1.-Human-GEM MAR01088
CoA[n] + H+[n] + N-acetyl-LTE4[n] = acetyl-CoA[n] + leukotriene E4[n]
ReversibleBalancedEC 2.3.1.-Human-GEM MAR01091
H2O[c] + leukotriene A4[c] = 12-epi-LTB4[c]
Left to rightBalancedHuman-GEM MAR01092
5,6-epoxytetraene[c] + H2O[c] + NADP+[c] = H+[c] + leukotriene A4[c] + NADPH[c] + O2[c]
ReversibleBalancedEC 1.13.11.31, 1.13.11.34Human-GEM MAR01093
H+[n] + leukotriene A4[n] + NADPH[n] + O2[n] = 5,6-epoxytetraene[n] + H2O[n] + NADP+[n]
Left to rightBalancedEC 1.13.11.31, 1.13.11.34Human-GEM MAR01096
15-oxo-lipoxin A4[c] + H+[c] + NADH[c] = lipoxin A4[c] + NAD+[c]
ReversibleBalancedEC 1.1.1.141Human-GEM MAR01097
13,14-dihydro-15-oxo-lipoxin A4[c] + NADP+[c] = 15-oxo-lipoxin A4[c] + H+[c] + NADPH[c]
ReversibleBalancedEC 1.1.1.-Human-GEM MAR01098
13,14-dihydro-15-oxo-lipoxin A4[c] + H+[c] + NADPH[c] = 13,14-dihydro-lipoxin A4[c] + NADP+[c]
ReversibleBalancedEC 1.1.1.141Human-GEM MAR01099
leukotriene B4[c] + NAD+[c] = 12-keto-LTB4[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.184Human-GEM MAR01100
leukotriene B4[m] + NAD+[m] = 12-keto-LTB4[m] + H+[m] + NADH[m]
Left to rightBalancedEC 1.1.1.184Human-GEM MAR01101
leukotriene B4[m] + NADP+[m] = 12-keto-LTB4[m] + H+[m] + NADPH[m]
Left to rightBalancedEC 1.1.1.184Human-GEM MAR01102
leukotriene B4[r] + NAD+[r] = 12-keto-LTB4[r] + H+[r] + NADH[r]
Left to rightBalancedEC 1.1.1.184Human-GEM MAR01103
leukotriene B4[x] + NADP+[x] = 12-keto-LTB4[x] + H+[x] + NADPH[x]
Left to rightBalancedEC 1.1.1.184Human-GEM MAR01105
leukotriene B4[x] + NAD+[x] = 12-keto-LTB4[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.184Human-GEM MAR01106
12-keto-LTB4[c] + H+[c] + NADPH[c] + O2[c] = 12-oxo-20-hydroxy-LTB4[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01107
12-keto-LTB4[r] + H+[r] + NADPH[r] + O2[r] = 12-oxo-20-hydroxy-LTB4[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01108
12-oxo-20-hydroxy-LTB4[c] + H+[c] + NADPH[c] + O2[c] = 12-oxo-20-dihydroxy-LTB4[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01109
12-oxo-20-hydroxy-LTB4[r] + H+[r] + NADPH[r] + O2[r] = 12-oxo-20-dihydroxy-LTB4[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01110
12-oxo-20-dihydroxy-LTB4[c] + H+[c] + NADPH[c] + O2[c] = 12-oxo-20-trihydroxy-LTB4[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01111
12-oxo-20-dihydroxy-LTB4[r] + H+[r] + NADPH[r] + O2[r] = 12-oxo-20-trihydroxy-LTB4[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01112
12,20-dioxo-LTB4[c] + H2O[c] = 12-oxo-20-dihydroxy-LTB4[c]
ReversibleBalancedHuman-GEM MAR01113
12-oxo-20-carboxy-LTB4[c] + H+[c] + H2O[c] = 12-oxo-20-trihydroxy-LTB4[c]
ReversibleBalancedHuman-GEM MAR01114
12-oxo-20-carboxy-LTB4[r] + H+[r] + H2O[r] = 12-oxo-20-trihydroxy-LTB4[r]
ReversibleBalancedHuman-GEM MAR01115
12-oxo-10,11-dihydro-20-COOH-LTB4[c] + NADP+[c] = 12-oxo-20-carboxy-LTB4[c] + H+[c] + NADPH[c]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR01116
12-oxo-10,11-dihydro-20-COOH-LTB4[r] + NADP+[r] = 12-oxo-20-carboxy-LTB4[r] + H+[r] + NADPH[r]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR01117
12-keto-LTB4[c] + GSH[c] = 12-oxo-c-LTB3[c]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR01119
12-keto-LTB4[m] + GSH[m] = 12-oxo-c-LTB3[m]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR01120
12-keto-LTB4[r] + GSH[r] = 12-oxo-c-LTB3[r]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR01121
12-keto-LTB4[x] + GSH[x] = 12-oxo-c-LTB3[x]
ReversibleBalancedEC 2.5.1.18Human-GEM MAR01122
10,11-dihydro-12R-hydroxy-LTC4[c] + NADP+[c] = 12-oxo-c-LTB3[c] + H+[c] + NADPH[c]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR01123
10,11-dihydro-12R-hydroxy-LTC4[m] + NADP+[m] = 12-oxo-c-LTB3[m] + H+[m] + NADPH[m]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR01124
10,11-dihydro-12R-hydroxy-LTC4[x] + NADP+[x] = 12-oxo-c-LTB3[x] + H+[x] + NADPH[x]
ReversibleBalancedEC 1.1.1.184Human-GEM MAR01125
H+[c] + leukotriene B4[c] + NADPH[c] + O2[c] = 20-OH-LTB4[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01126
H+[m] + leukotriene B4[m] + NADPH[m] + O2[m] = 20-OH-LTB4[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01127
H+[r] + leukotriene B4[r] + NADPH[r] + O2[r] = 20-OH-LTB4[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01128
20-OH-LTB4[c] + NAD+[c] = 20-oxo-LTB4[c] + H+[c] + NADH[c]
ReversibleBalancedEC 1.1.1.1Human-GEM MAR01129
20-OH-LTB4[m] + NAD+[m] = 20-oxo-LTB4[m] + H+[m] + NADH[m]
ReversibleBalancedEC 1.1.1.1Human-GEM MAR01130
20-OH-LTB4[r] + NAD+[r] = 20-oxo-LTB4[r] + H+[r] + NADH[r]
ReversibleBalancedEC 1.1.1.1Human-GEM MAR01131
20-COOH-LTB4[c] + 2 H+[c] + NADH[c] = 20-oxo-LTB4[c] + H2O[c] + NAD+[c]
ReversibleBalancedEC 1.2.1.3Human-GEM MAR01132
20-COOH-LTB4[m] + 2 H+[m] + NADH[m] = 20-oxo-LTB4[m] + H2O[m] + NAD+[m]
ReversibleBalancedEC 1.2.1.3Human-GEM MAR01133
20-COOH-LTB4[r] + 2 H+[r] + NADH[r] = 20-oxo-LTB4[r] + H2O[r] + NAD+[r]
ReversibleBalancedEC 1.2.1.3Human-GEM MAR01134
20-dihydroxy-LTB4[r] = 20-oxo-LTB4[r] + H2O[r]
ReversibleBalancedHuman-GEM MAR01136
20-OH-LTB4[c] + H+[c] + NADPH[c] + O2[c] = 20-dihydroxy-LTB4[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01137
20-OH-LTB4[r] + H+[r] + NADPH[r] + O2[r] = 20-dihydroxy-LTB4[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01138
20-dihydroxy-LTB4[c] + H+[c] + NADPH[c] + O2[c] = 20-trihydroxy-LTB4[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.94Human-GEM MAR01139