Reactions

Reactions

3 reactions in Heme degradation

• Heme Oxygenase 1

  5 H+[c] + heme[c] + 3 NADPH[c] + 3 O2[c] = biliverdin[c] + CO[c] + Fe2+[c] + 3 H2O[c] + 3 NADP+[c]

  → Left to rightBalancedEC 1.14.14.18Human-GEM MAR01450

• Bilirubin Di-Glucuronide Production

  bilirubin-monoglucuronoside[r] + UDP-glucuronate[r] = bilirubin-bisglucuronoside[r] + UDP[r]

  → Left to rightBalancedEC 2.4.1.17Human-GEM MAR07813

• UDP-Glucuronosyltransferase 1-10 Precursor, Cytosol

  bilirubin[c] + UDP-glucuronate[c] = bilirubin-monoglucuronoside[c] + UDP[c]

  ⇌ ReversibleBalancedHuman-GEM MAR11321