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Subsystem: Glucocorticoid biosynthesis Remove
11 reactions in Glucocorticoid biosynthesis
NAD+[c] + pregnenolone[c] = H+[c] + NADH[c] + pregn-5-ene-3,20-dione[c]
Left to rightBalancedEC 1.1.1.145Human-GEM MAR01979
pregn-5-ene-3,20-dione[c] = progesterone[c]
Left to rightBalancedEC 5.3.3.1Human-GEM MAR01980
H+[c] + NADPH[c] + O2[c] + progesterone[c] = 17alpha-hydroxyprogesterone[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.19Human-GEM MAR01981
17alpha-hydroxyprogesterone[c] + NADPH[c] + O2[c] = 4-androstene-3,17-dione[c] + acetate[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.99.-Human-GEM MAR01985
17alpha-hydroxyprogesterone[r] + NADPH[r] + O2[r] = 4-androstene-3,17-dione[r] + acetate[r] + H2O[r] + NADP+[r]
Reversible
17alpha-hydroxyprogesterone[c] + H+[c] + NADPH[c] + O2[c] = 11-deoxycortisol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.16Human-GEM MAR01988
11-deoxycortisol[m] + H+[m] + NADPH[m] + O2[m] = cortisol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.4Human-GEM MAR01995
cortisol[c] + NADP+[c] = cortisone[c] + H+[c] + NADPH[c]
Left to rightBalancedEC 1.1.1.146Human-GEM MAR01996
cortisol[c] + H+[c] + 2 NADPH[c] + O2[c] = 11beta-hydroxyandrost-4-ene-3,17-dione[c] + acetate[c] + 2 H2O[c] + 2 NADP+[c]
Left to rightBalancedEC 1.14.15.4, 1.14.14.19Human-GEM MAR01999
cortisol[m] + H+[m] + 2 NADPH[m] + O2[m] = 11beta-hydroxyandrost-4-ene-3,17-dione[m] + acetate[m] + 2 H2O[m] + 2 NADP+[m]
Left to rightBalancedEC 1.14.15.4, 1.14.99.-Human-GEM MAR02000
cortisol[r] + H+[r] + 2 NADPH[r] + O2[r] = 11beta-hydroxyandrost-4-ene-3,17-dione[r] + acetate[r] + 2 H2O[r] + 2 NADP+[r]
Left to rightBalancedEC 1.14.15.4, 1.14.99.-Human-GEM MAR02001