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Subsystem: Chondroitin / heparan sulfate biosynthesis Remove
45 reactions in Chondroitin / heparan sulfate biosynthesis
[protein]-L-serine[r] + UDP-xylose[r] = H+[r] + UDP[r] + Xyl-L-Ser-[protein][r]
Left to rightBalance undeterminableEC 2.4.2.26Human-GEM MAR07200
UDP-galactose[g] + Xyl-L-Ser-[protein][g] = Gal-Xyl-L-Ser-[protein][g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.133Human-GEM MAR07202
Gal-Xyl-L-Ser-[protein][g] + UDP-galactose[g] = Gal2-Xyl-L-Ser-[protein][g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.134Human-GEM MAR07203
Gal2-Xyl-L-Ser-[protein][g] + UDP-glucuronate[g] = 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.135Human-GEM MAR07205
3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein[g] + UDP-N-acetyl-D-galactosamine[g] = chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.174Human-GEM MAR07206
3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein[g] + UDP-N-acetylglucosamine[g] = H+[g] + heparan sulfate, precursor 1[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.223Human-GEM MAR07207
heparan sulfate, precursor 1[g] + UDP-glucuronate[g] = H+[g] + heparan sulfate, precursor 2[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.224, 2.4.1.225Human-GEM MAR07208
heparan sulfate, precursor 2[g] + UDP-N-acetylglucosamine[g] = H+[g] + heparan sulfate, precursor 3[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Human-GEM MAR07209
heparan sulfate, precursor 3[g] + UDP-glucuronate[g] = H+[g] + heparan sulfate, precursor 4[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.224, 2.4.1.225Human-GEM MAR07210
heparan sulfate, precursor 4[g] + UDP-N-acetylglucosamine[g] = H+[g] + heparan sulfate, precursor 5[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Human-GEM MAR07211
heparan sulfate, precursor 5[g] + UDP-glucuronate[g] = H+[g] + heparan sulfate, precursor 6[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.224, 2.4.1.225Human-GEM MAR07212
heparan sulfate, precursor 6[g] + UDP-N-acetylglucosamine[g] = H+[g] + heparan sulfate, precursor 7[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Human-GEM MAR07213
heparan sulfate, precursor 7[g] + UDP-glucuronate[g] = H+[g] + heparan sulfate, precursor 8[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.224, 2.4.1.225Human-GEM MAR07214
heparan sulfate, precursor 8[g] + UDP-N-acetylglucosamine[g] = H+[g] + heparan sulfate, precursor 9[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Human-GEM MAR07215
4 H2O[g] + heparan sulfate, precursor 9[g] + 4 PAPS[g] = 4 acetate[g] + 4 H+[g] + heparan sulfate, precursor 10[g] + 4 PAP[g]
Left to rightBalance undeterminableEC 2.8.2.8Human-GEM MAR07216
heparan sulfate, precursor 10[g] = heparan sulfate, precursor 11[g]
Left to rightBalance undeterminableEC 5.1.3.17Human-GEM MAR07217
heparan sulfate, precursor 11[g] + 2 PAPS[g] = 2 H+[g] + heparan sulfate, precursor 12[g] + 2 PAP[g]
Left to rightBalance undeterminableEC 2.8.2.-Human-GEM MAR07218
heparan sulfate, precursor 12[g] + 3 PAPS[g] = 3 H+[g] + heparan sulfate, precursor 13[g] + 3 PAP[g]
Left to rightBalance undeterminableEC 2.8.2.-Human-GEM MAR07219
heparan sulfate, precursor 13[g] + PAPS[g] = H+[g] + heparan sulfate, precursor 14[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.23Human-GEM MAR07220
heparan sulfate, precursor 14[g] + PAPS[g] = H+[g] + heparan sulfate, precursor 15[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.23, 2.8.2.29Human-GEM MAR07221
heparan sulfate, precursor 15[g] + PAPS[g] = H+[g] + heparan sulfate proteoglycan[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.23, 2.8.2.30Human-GEM MAR07222
chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1[g] + 2 PAPS[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 2[g] + 2 H+[g] + 2 PAP[g]
Left to rightBalance undeterminableHuman-GEM MAR07490
chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))[g] + 2 PAPS[g] = chondroitin sulfate A (GalNAc4S-GlcA), B (IdoA2S-GalNAc4S), and E (GalNAc4,6diS-GlcA), precursor 1[g] + 2 H+[g] + 2 PAP[g]
Left to rightBalance undeterminableEC 2.8.2.5, 2.8.2.35Human-GEM MAR07491
chondroitin sulfate A (GalNAc4S-GlcA), B (IdoA2S-GalNAc4S), and E (GalNAc4,6diS-GlcA), precursor 1[g] + 2 PAPS[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 2[g] + 2 H+[g] + 2 PAP[g]
Left to rightBalance undeterminableEC 2.8.2.17Human-GEM MAR07492
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 2[g] + UDP-glucuronate[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 3[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Human-GEM MAR07493
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 3[g] + UDP-N-acetylglucosamine[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 4[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.226Human-GEM MAR07494
chondroitin sulfate A (GalNAc4S-GlcA), B (IdoA2S-GalNAc4S), and E (GalNAc4,6diS-GlcA), precursor 1[g] + UDP-glucuronate[g] = chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 2[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Human-GEM MAR07495
chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 2[g] + UDP-N-acetylglucosamine[g] = chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 3[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.226Human-GEM MAR07496
chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 3[g] = chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4[g]
Left to rightBalance undeterminableHuman-GEM MAR07497
chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 3[g] + PAPS[g] = chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.-Human-GEM MAR07498
chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4[g] + PAPS[g] = chondroitin sulfate B (IdoA2S-GalNAc4s), precursor 5[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.5, 2.8.2.35Human-GEM MAR07509
chondroitin sulfate B (IdoA2S-GalNAc4s), precursor 5[g] + PAPS[g] = chondroitin sulfate B - dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 5.1.3.19, 2.8.2.-Human-GEM MAR07510
chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))[g] + 2 PAPS[g] = chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1[g] + 2 H+[g] + 2 PAP[g]
Left to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Human-GEM MAR07519
chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1[g] + UDP-glucuronate[g] = chondroitin sulfate C (GalNAc6S-GlcA), precursor 2[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Human-GEM MAR07520
chondroitin sulfate C (GalNAc6S-GlcA), precursor 2[g] + UDP-N-acetylglucosamine[g] = chondroitin sulfate C (GalNAc6S-GlcA), precursor 3[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.226Human-GEM MAR07521
chondroitin sulfate C (GalNAc6S-GlcA), precursor 3[g] + PAPS[g] = chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Human-GEM MAR07522
chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1[g] + PAPS[g] = chondroitin sulfate D (GlcNAc6S-GlcA2S) precursor 2[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.-Human-GEM MAR07534
chondroitin sulfate D (GlcNAc6S-GlcA2S) precursor 2[g] + UDP-glucuronate[g] = chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 3[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.175, 2.4.1.226Human-GEM MAR07535
chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 3[g] + UDP-N-acetylglucosamine[g] = chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 4[g] + H+[g] + UDP[g]
Left to rightBalance undeterminableEC 2.4.1.226Human-GEM MAR07536
chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 4[g] + PAPS[g] = chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 5[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Human-GEM MAR07537
chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 5[g] + PAPS[g] = chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.-Human-GEM MAR07538
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 4[g] + PAPS[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5a[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.-Human-GEM MAR07551
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 4[g] + PAPS[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.17, 2.8.2.33Human-GEM MAR07552
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5a[g] + PAPS[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableEC 2.8.2.17Human-GEM MAR07553
chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b[g] + PAPS[g] = chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan[g] + H+[g] + PAP[g]
Left to rightBalance undeterminableHuman-GEM MAR07554