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Subsystem: Cholesterol biosynthesis 1 (Bloch pathway) Remove
27 reactions in Cholesterol biosynthesis 1 (Bloch pathway)
2 H+[c] + HMG-CoA[c] + 2 NADPH[c] = (R)-mevalonate[c] + CoA[c] + 2 NADP+[c]
Left to rightBalancedEC 1.1.1.34Human-GEM MAR01440
(R)-mevalonate[c] + ATP[c] = (R)-5-phosphomevalonate[c] + ADP[c] + H+[c]
Left to rightBalancedEC 2.7.1.36Human-GEM MAR01445
(R)-5-diphosphomevalonate[c] + ADP[c] = (R)-5-phosphomevalonate[c] + ATP[c]
ReversibleBalancedEC 2.7.4.2Human-GEM MAR01448
isopentenyl-pPP[c] = dimethylallyl-PP[c]
Left to rightBalancedEC 5.3.3.2Human-GEM MAR01454
2 farnesyl-PP[c] = PPi[c] + presqualene-PP[c]
Left to rightBalancedEC 2.5.1.21
H+[c] + NADPH[c] + presqualene-PP[c] = NADP+[c] + PPi[c] + squalene[c]
Left to rightBalancedEC 2.5.1.21Human-GEM MAR01467
H+[c] + NADPH[c] + O2[c] + squalene[c] = H2O[c] + NADP+[c] + squalene 2,3-oxide[c]
Left to rightBalancedEC 1.14.14.17Human-GEM MAR01470
squalene 2,3-oxide[c] = lanosterol[c]
Left to rightBalancedEC 5.4.99.7Human-GEM MAR01473
H+[c] + lanosterol[c] + NADPH[c] + O2[c] = 4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Human-GEM MAR01477
4,4-dimethyl-14alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Human-GEM MAR01478
4,4-dimethyl-14alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + NADPH[c] + O2[c] = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[c] + formate[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.154Human-GEM MAR01479
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol[c] + H+[c] + NADPH[c] = 14-demethyllanosterol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.70Human-GEM MAR01484
14-demethyllanosterol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01490
4alpha-hydroxymethyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01493
4alpha-formyl-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01494
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + NADP+[c] = 3-keto-4-methylzymosterol[c] + CO2[c] + H+[c] + NADPH[c]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR01495
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + NAD+[c] = 3-keto-4-methylzymosterol[c] + CO2[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR01496
3-keto-4-methylzymosterol[c] + 3 H+[c] + NADP+[c] = 4alpha-methylzymosterol[c] + NADPH[c]
ReversibleUnbalancedEC 1.1.1.270Human-GEM MAR01500
4alpha-methylzymosterol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01502
4alpha-hydroxymethyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01503
4alpha-formyl-5alpha-cholesta-8,24-dien-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.18.9Human-GEM MAR01504
4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol[c] + NADP+[c] = 5alpha-cholesta-8,24-dien-3-one[c] + CO2[c] + H+[c] + NADPH[c]
Left to rightBalancedEC 1.1.1.170Human-GEM MAR01505
5alpha-cholesta-8,24-dien-3-one[c] + H+[c] + NADPH[c] = NADP+[c] + zymosterol[c]
Left to rightBalancedEC 1.1.1.270Human-GEM MAR01509
zymosterol[c] = 5alpha-cholesta-7,24-dien-3beta-ol[c]
Left to rightBalancedEC 5.3.3.5Human-GEM MAR01512
5alpha-cholesta-7,24-dien-3beta-ol[c] + H+[c] + NADPH[c] + O2[c] = 7-dehydrodesmosterol[c] + 2 H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.19.20Human-GEM MAR01516
7-dehydrodesmosterol[c] + H+[c] + NADPH[c] = desmosterol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.21Human-GEM MAR01519
desmosterol[c] + H+[c] + NADPH[c] = cholesterol[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.72Human-GEM MAR01526