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Subsystem: Biopterin metabolism Remove
27 reactions in Biopterin metabolism
O2[c] + tetrahydrobiopterin[c] + tryptophan[c] = 5-hydroxy-L-tryptophan[c] + dihydrobiopterin[c] + H2O[c]
Left to rightBalancedEC 1.14.16.4Human-GEM MAR02119
GTP[c] + H2O[c] = 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin[c] + formate[c] + H+[c]
Left to rightBalancedEC 3.5.4.16Human-GEM MAR04160
GTP[n] + H2O[n] = 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin[n] + formate[n] + H+[n]
Left to rightBalancedEC 3.5.4.16Human-GEM MAR04162
6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin[c] = 6-pyruvoyltetrahydropterin[c] + triphosphate[c]
Left to rightBalancedEC 4.2.3.12Human-GEM MAR04163
6-pyruvoyltetrahydropterin[c] + 2 H+[c] + 2 NADPH[c] = 2 NADP+[c] + tetrahydrobiopterin[c]
6-pyruvoyltetrahydropterin[c] + H+[c] + NADPH[c] = 6-lactoyl-5,6,7,8-tetrahydropterin[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.153, 1.1.1.220Human-GEM MAR04166
6-lactoyl-5,6,7,8-tetrahydropterin[c] + H+[c] + NADPH[c] = NADP+[c] + tetrahydrobiopterin[c]
Left to rightBalancedEC 1.1.1.153Human-GEM MAR04167
GTP[c] + H2O[c] = formamidopyrimidine nucleoside triphosphate[c]
Left to rightBalancedEC 3.5.4.16Human-GEM MAR04169
GTP[n] + H2O[n] = formamidopyrimidine nucleoside triphosphate[n]
Left to rightBalancedEC 3.5.4.16Human-GEM MAR04170
dihydrobiopterin[c] + H+[c] + NADPH[c] = NADP+[c] + tetrahydrobiopterin[c]
ReversibleBalancedEC 1.5.1.34Human-GEM MAR04523
4alpha-hydroxytetrahydrobiopterin[c] = H2O[c] + O2-4a-cyclic-tetrahydrobiopterin[c]
ReversibleBalancedEC 4.2.1.96Human-GEM MAR04539
4alpha-hydroxytetrahydrobiopterin[n] = H2O[n] + O2-4a-cyclic-tetrahydrobiopterin[n]
ReversibleBalancedEC 4.2.1.96Human-GEM MAR04540
O2-4a-cyclic-tetrahydrobiopterin[c] = quinonoid dihydrobiopterin[c]
ReversibleBalancedEC 4.2.1.96Human-GEM MAR04541
O2-4a-cyclic-tetrahydrobiopterin[n] = quinonoid dihydrobiopterin[n]
ReversibleBalancedEC 4.2.1.96Human-GEM MAR04542
4alpha-hydroxytetrahydrobiopterin[c] = H2O[c] + quinonoid dihydrobiopterin[c]
ReversibleBalancedEC 4.2.1.96Human-GEM MAR04543
4alpha-hydroxytetrahydrobiopterin[n] = H2O[n] + quinonoid dihydrobiopterin[n]
ReversibleBalancedEC 4.2.1.96Human-GEM MAR04544
6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin[c] + 3 H2O[c] = dihydroneopterin[c] + 2 H+[c] + 3 Pi[c]
Left to rightBalancedEC 3.1.3.1Human-GEM MAR04816
2,5-diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-amino-4-oxopyrimidine[c] = 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin[c] + H2O[c]
ReversibleBalancedEC 3.5.4.16Human-GEM MAR04817
2,5-diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-amino-4-oxopyrimidine[n] = 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin[n] + H2O[n]
ReversibleBalancedEC 3.5.4.16Human-GEM MAR04818
2,5-diaminopyrimidine nucleoside triphosphate[c] + formate[c] + H+[c] = formamidopyrimidine nucleoside triphosphate[c] + H2O[c]
ReversibleBalancedEC 3.5.4.16Human-GEM MAR04833
2,5-diaminopyrimidine nucleoside triphosphate[n] + formate[n] + H+[n] = formamidopyrimidine nucleoside triphosphate[n] + H2O[n]
ReversibleBalancedEC 3.5.4.16Human-GEM MAR04834
2,5-diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-amino-4-oxopyrimidine[c] = 2,5-diaminopyrimidine nucleoside triphosphate[c]
ReversibleBalancedEC 3.5.4.16Human-GEM MAR04835
2,5-diamino-6-(5-triphosphoryl-3,4-trihydroxy-2-oxopentyl)-amino-4-oxopyrimidine[n] = 2,5-diaminopyrimidine nucleoside triphosphate[n]
ReversibleBalancedEC 3.5.4.16Human-GEM MAR04836
4alpha-hydroxytetrahydrobiopterin[c] = dihydrobiopterin[c] + H2O[c]
Left to rightBalancedEC 4.2.1.96Human-GEM MAR08538
6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin[n] = 6-pyruvoyltetrahydropterin[n] + triphosphate[n]
Left to rightBalancedEC 4.2.3.12Human-GEM MAR08738
6-pyruvoyltetrahydropterin[n] + 2 H+[n] + 2 NADPH[n] = 2 NADP+[n] + tetrahydrobiopterin[n]
Left to rightBalancedEC 1.1.1.153Human-GEM MAR08739
5-methyl-THF[c] + dihydrobiopterin[c] = 5,10-methylene-THF[c] + H+[c] + tetrahydrobiopterin[c]
Left to rightBalancedHuman-GEM MAR08740