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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

4,701–4,750 of 18,558 reactions from Rhea

2-demethylmenaquinone-8 + NADH + H(+) = 2-demethylmenaquinol-8 + NAD(+)
Direction not assertedBalancedRhea 30507
2-demethylmenaquinone-8 + NADPH + H(+) = 2-demethylmenaquinol-8 + NADP(+)
Direction not assertedBalancedRhea 30511
S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = thermospermine + S-methyl-5'-thioadenosine + H(+)
Direction not assertedBalancedRhea 30515
phosphoenolpyruvate + GTP + H(+) = enolpyruvoyl-2-diphospho-5'-guanosine + diphosphate
Direction not assertedBalancedRhea 30519
oxidized coenzyme F420-1 + GTP + L-glutamate = oxidized coenzyme F420-2 + GDP + phosphate + H(+)
Direction not assertedBalancedRhea 30523
P(1),P(5)-bis(5'-adenosyl) pentaphosphate + H2O = ADP + ATP + 2 H(+)
Left to rightBalancedRhea 30527
biotinate sulfoxide + NADH + H(+) = biotin + NAD(+) + H2O

Direction not assertedBalancedRhea 30531

biotinate sulfoxide + NADPH + H(+) = biotin + NADP(+) + H2O

Direction not assertedBalancedRhea 30535

(R)-carnitinyl-CoA = (S)-carnitinyl-CoA

Direction not assertedBalancedRhea 30539

(S)-carnitine + ATP + CoA = (S)-carnitinyl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 30543

(3S)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O

Right to leftBalancedRhea 30547

beta-D-glucose + acetyl-CoA = 6-O-acetyl-beta-D-glucose + CoA

Direction not assertedBalancedRhea 30551

oxidized coenzyme F420-0 + GTP + L-glutamate = oxidized coenzyme F420-1 + GDP + phosphate + H(+)

Direction not assertedBalancedRhea 30555

GTP + H2O = guanosine + triphosphate + H(+)

Direction not assertedBalancedRhea 30559

dimethylallyl diphosphate + L-tryptophan = 7-(3-methylbut-2-enyl)-L-tryptophan + diphosphate

Direction not assertedBalancedRhea 30563

5,6,7,8-tetrahydromethanopterin + L-glutamate + ATP = 5,6,7,8-tetrahydrosarcinapterin + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 30567

3 2,3-dihydroxybenzoate + 3 L-serine + 6 ATP = enterobactin + 6 AMP + 6 diphosphate + 4 H(+)

Direction not assertedBalancedRhea 30571

protoporphyrinogen IX + 3 menaquinone-8 = protoporphyrin IX + 3 menaquinol-8

Direction not assertedBalancedRhea 30575

O-phospho-L-threonine + H2O = L-threonine + phosphate

Direction not assertedBalancedRhea 30579

2-demethylmenaquinol-8 + trimethylamine N-oxide + H(+) = 2-demethylmenaquinone-8 + trimethylamine + H2O

Direction not assertedBalancedRhea 30583

2-demethylmenaquinol-8 + dimethyl sulfoxide = 2-demethylmenaquinone-8 + dimethyl sulfide + H2O

Direction not assertedBalancedRhea 30587

tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 30591

4-hydroxyphenylacetate + FADH2 + O2 = 3,4-dihydroxyphenylacetate + FAD + H2O + H(+)

Direction not assertedBalancedRhea 30595

15-cis-phytoene + 3 A = all-trans-neurosporene + 3 AH2

Direction not assertedBalancedRhea 30599

15-cis-phytoene + A = all-trans-phytofluene + AH2

Direction not assertedBalancedRhea 30603

all-trans-phytofluene + A = all-trans-zeta-carotene + AH2

Direction not assertedBalancedRhea 30607

all-trans-zeta-carotene + A = all-trans-neurosporene + AH2

Direction not assertedBalancedRhea 30611

15-cis-phytoene + 2 A = all-trans-zeta-carotene + 2 AH2

Direction not assertedBalancedRhea 30615

all-trans-zeta-carotene + 2 A = all-trans-lycopene + 2 AH2

Direction not assertedBalancedRhea 30619

all-trans-neurosporene + A = all-trans-lycopene + AH2

Direction not assertedBalancedRhea 30623

(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + NADH + H(+)

Direction not assertedBalancedRhea 30627

alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 30631

an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)

Left to rightBalance undeterminableRhea 30635

(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)

Direction not assertedBalancedRhea 30639

S-methyl-5'-thioinosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + hypoxanthine

Direction not assertedBalancedRhea 30643

1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate

Direction not assertedBalancedRhea 30647

dUMP + ATP = dUDP + ADP

Direction not assertedBalancedRhea 30655

4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate

Direction not assertedBalancedRhea 30659

3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H

Direction not assertedBalancedRhea 30663

N,N'-diacetylchitobiose + H2O = 2 N-acetyl-D-glucosamine

Left to rightBalancedRhea 30671

tetrahymanol = squalene + H2O

Direction not assertedBalancedRhea 30675

D-cellobiose + H2O = beta-D-glucose + D-glucose

Left to rightBalancedRhea 30679

UDP-N-acetyl-alpha-D-glucosamine + H2O = aldehydo-N-acetyl-D-mannosamine + UDP + H(+)

Left to rightBalancedRhea 30683

(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Direction not assertedBalancedRhea 30687

methanol + H2O2 = formaldehyde + 2 H2O

Direction not assertedBalancedRhea 30691

3-aminopropanal + NAD(+) + H2O = beta-alanine + NADH + 2 H(+)

Direction not assertedBalancedRhea 30695

beta-alanine + 2-oxoglutarate = 3-oxopropanoate + L-glutamate

Direction not assertedBalancedRhea 30699

salicylate + H(+) = phenol + CO2

Direction not assertedBalancedRhea 30703

putrescine + pyruvate = 4-aminobutanal + L-alanine

Direction not assertedBalancedRhea 30707

(S)-linalool = beta-myrcene + H2O

Direction not assertedBalancedRhea 30711

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